N-Benzyl-N-{(1R,3S)-1-((2S,3S,5S,7S,9S)-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]non-7-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-hydroxylamine

Base Information

• Chemical Name: N-Benzyl-N-{(1R,3S)-1-((2S,3S,5S,7S,9S)-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]non-7-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-hydroxylamine
• CAS No.: 361460-38-0
• Molecular Formula: C₄₂H₆₀N₂O₆
• Molecular Weight: 688.948

Synonyms:N-Benzyl-N-{(1R,3S)-1-((2S,3S,5S,7S,9S)-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]non-7-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-hydroxylamine

Chemical Property of N-Benzyl-N-{(1R,3S)-1-((2S,3S,5S,7S,9S)-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]non-7-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-hydroxylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of N-Benzyl-N-{(1R,3S)-1-((2S,3S,5S,7S,9S)-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]non-7-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-hydroxylamine

There total 3 articles about N-Benzyl-N-{(1R,3S)-1-((2S,3S,5S,7S,9S)-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]non-7-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane (324763-39-5) + C25H32N2O3 (437656-17-2,361460-37-9) → N-Benzyl-N-{(1S,3S)-1-((2S,3S,5S,7S,9S)-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]non-7-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-hydroxylamine (361460-39-1) + N-Benzyl-N-{(1R,3S)-1-((2S,3S,5S,7S,9S)-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]non-7-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-hydroxylamine (361460-38-0)

Guidance literature:

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane; With magnesium; ethylene dibromide; In tetrahydrofuran; at 45 ℃; for 1h;

C₂₅H₃₂N₂O₃; In tetrahydrofuran; at -40 ℃; for 15h;

DOI:10.1016/S0040-4039(01)00883-8

Reference yield:

(2S,3S,5R,7S,9S)-9-Isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]nonane-7-carbaldehyde (324763-44-2) → N-Benzyl-N-{(1R,3S)-1-((2S,3S,5S,7S,9S)-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]non-7-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-hydroxylamine (361460-38-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 88 percent / sodium sulfate / CH₂Cl₂ / 2 h / 20 °C

2.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 1 h / 45 °C

2.2: 1,3-dimethyl-3,4,5-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran / 15 h / -10 °C

With magnesium; sodium sulfate; ethylene dibromide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(01)00883-8

Reference yield:

((2S,3S,5R,7S,9S)-9-Isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]non-7-yl)-methanol (324763-42-0) → N-Benzyl-N-{(1R,3S)-1-((2S,3S,5S,7S,9S)-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]non-7-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-hydroxylamine (361460-38-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: SO₃*pyridine; Et₃N; DMSO / CH₂Cl₂ / 1 h / 0 - 20 °C

2.1: 88 percent / sodium sulfate / CH₂Cl₂ / 2 h / 20 °C

3.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 1 h / 45 °C

3.2: 1,3-dimethyl-3,4,5-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran / 15 h / -10 °C

With pyridine-SO₃ complex; magnesium; dimethyl sulfoxide; sodium sulfate; ethylene dibromide; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(01)00883-8

upstream raw materials:

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

C₂₅H₃₂N₂O₃

(2S,3S,5R,7S,9S)-9-Isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]nonane-7-carbaldehyde

((2S,3S,5R,7S,9S)-9-Isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]non-7-yl)-methanol

Downstream raw materials:

(2S,4S,5R,7S)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methyl-2-isopropylnonanamide

(2S,4S,5R,7S)-5-Benzylamino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide

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