7-Azabicyclo[4.1.0]heptan-2-ol,4-(1-methylethyl)-,(1R,2R,4R,6R)-rel-(9CI)

Base Information

Chemical Name:7-Azabicyclo[4.1.0]heptan-2-ol,4-(1-methylethyl)-,(1R,2R,4R,6R)-rel-(9CI)
CAS No.:217310-20-8
Molecular Formula:C₉H₁₇NO
Molecular Weight:155.24
Hs Code.:
Mol file:217310-20-8.mol

Synonyms:7-Azabicyclo[4.1.0]heptan-2-ol,4-(1-methylethyl)-,(1R,2R,4R,6R)-rel-(9CI)

Suppliers and Price of 7-Azabicyclo[4.1.0]heptan-2-ol,4-(1-methylethyl)-,(1R,2R,4R,6R)-rel-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 7-Azabicyclo[4.1.0]heptan-2-ol,4-(1-methylethyl)-,(1R,2R,4R,6R)-rel-(9CI)

Chemical Property:

PSA：0.00000
LogP:0.00000

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7-Azabicyclo[4.1.0]heptan-2-ol,4-(1-methylethyl)-,(1R,2R,4R,6R)-rel-(9CI)

There total 6 articles about 7-Azabicyclo[4.1.0]heptan-2-ol,4-(1-methylethyl)-,(1R,2R,4R,6R)-rel-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: (1R,2S,3R,5R)-3-Azido-5-isopropyl-cyclohexane-1,2-diol

: 217310-20-8
(1R,2R,4R,6R)-4-Isopropyl-7-aza-bicyclo[4.1.0]heptan-2-ol

Guidance literature:: With triphenylphosphine; In acetonitrile;
DOI:10.1016/S0040-4039(98)01796-1

Reference yield:

: 18456-87-6
5-isopropyl-1,3-cyclohexanedione

: 217310-20-8
(1R,2R,4R,6R)-4-Isopropyl-7-aza-bicyclo[4.1.0]heptan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / p-TsOH / benzene / Heating

2: 1.) LAH; 2.) H₃O⁺ / 1.) ether

3: 93 percent / LAH / diethyl ether

4: 88 percent / mCPBA / CH₂Cl₂ / 0 °C

5: 93 percent / NaN₃, NH₄Cl / methanol / Heating

6: 91 percent / Ph₃P / acetonitrile

With lithium aluminium tetrahydride; sodium azide; oxonium; ammonium chloride; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In methanol; diethyl ether; dichloromethane; acetonitrile; benzene;
DOI:10.1016/S0040-4039(98)01796-1

Reference yield:

: 217310-18-4
(1R,2R,4S,6S)-4-Isopropyl-7-oxa-bicyclo[4.1.0]heptan-2-ol

: 217310-20-8
(1R,2R,4R,6R)-4-Isopropyl-7-aza-bicyclo[4.1.0]heptan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / NaN₃, NH₄Cl / methanol / Heating

2: 91 percent / Ph₃P / acetonitrile

With sodium azide; ammonium chloride; triphenylphosphine; In methanol; acetonitrile;
DOI:10.1016/S0040-4039(98)01796-1