N-cyclopropyl-4-(2-(methylsulfonyl)-4-((2-morpholinoethyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide trifluoroacetic acid

Base Information

• Chemical Name: N-cyclopropyl-4-(2-(methylsulfonyl)-4-((2-morpholinoethyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide trifluoroacetic acid
• CAS No.: 1610680-33-5
• Molecular Formula: C₂HF₃O₂*C₂₂H₂₇N₇O₄S
• Molecular Weight: 599.591
• Mol file: 1610680-33-5.mol

Synonyms:N-cyclopropyl-4-(2-(methylsulfonyl)-4-((2-morpholinoethyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide trifluoroacetic acid

Chemical Property of N-cyclopropyl-4-(2-(methylsulfonyl)-4-((2-morpholinoethyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide trifluoroacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-cyclopropyl-4-(2-(methylsulfonyl)-4-((2-morpholinoethyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide trifluoroacetic acid

There total 7 articles about N-cyclopropyl-4-(2-(methylsulfonyl)-4-((2-morpholinoethyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

N-cyclopropyl-4-(4-((4-methoxybenzyl)(2-morpholinoethyl)amino)-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide (1610680-18-6) + trifluoroacetic acid (76-05-1) → N-cyclopropyl-4-(2-(methylsulfonyl)-4-((2-morpholinoethyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide trifluoroacetic acid (1610680-33-5)

Guidance literature:

N-cyclopropyl-4-(4-((4-methoxybenzyl)(2-morpholinoethyl)amino)-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide; trifluoroacetic acid; In dichloromethane; at 80 ℃; for 2h;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; at 20 ℃; for 5h;

DOI:10.1016/j.bmcl.2016.06.021

Reference yield: 47.0%

C22H27N7O2S*C2HF3O2 → N-cyclopropyl-4-(2-(methylsulfonyl)-4-((2-morpholinoethyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide trifluoroacetic acid (1610680-33-5)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

N-cyclopropyl-4-(4-((4-methoxybenzyl)(2-morpholinoethyl)amino)-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide (1610680-18-6) → N-cyclopropyl-4-(2-(methylsulfonyl)-4-((2-morpholinoethyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide trifluoroacetic acid (1610680-33-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 2 h / 80 °C / Microwave irradiation

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 20 °C

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

upstream raw materials:

N-cyclopropyl-4-(4-((4-methoxybenzyl)(2-morpholinoethyl)amino)-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide

4-(2-AMINOETHYL)MORPHOLINE

trifluoroacetic acid

8-bromo-2-(methylthio)-4-chloropyrazolo<1,5-a>-1,3,5-triazine

Downstream raw materials:

N-cyclopropyl-4-(4-((2-morpholinoethyl)amino)-2-phenoxypyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide

N-cyclopropyl-4-(2-(4-hydroxypiperidin-1-yl)-4-((2-morpholinoethyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide