2-Chloro-2-fluoro-1-(piperidin-1-yl)ethan-1-one

Base Information

Chemical Name:2-Chloro-2-fluoro-1-(piperidin-1-yl)ethan-1-one
CAS No.:321-77-7
Molecular Formula:C₇H₁₁ClFNO
Molecular Weight:179.622
Hs Code.:2933399090
DSSTox Substance ID:DTXSID30577750
Mol file:321-77-7.mol

Synonyms:321-77-7;2-Chloro-2-Fluoro-1-(1-Piperidinyl)Ethanone;2-Chloro-2-fluoro-1-(piperidin-1-yl)ethan-1-one;DTXSID30577750

Suppliers and Price of 2-Chloro-2-fluoro-1-(piperidin-1-yl)ethan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-Chloro-2-fluoro-1-(piperidin-1-yl)ethan-1-one

Chemical Property:

Melting Point:34-35 °C
Boiling Point:74 °C(Press: 0.5 Torr)
PKA:-1.39±0.20(Predicted)
PSA：20.31000
Density:1.230±0.06 g/cm3(Predicted)
LogP:1.47120
XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:179.0513198
Heavy Atom Count:11
Complexity:147

Purity/Quality:: 99%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(CC1)C(=O)C(F)Cl

Technology Process of 2-Chloro-2-fluoro-1-(piperidin-1-yl)ethan-1-one

There total 2 articles about 2-Chloro-2-fluoro-1-(piperidin-1-yl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 312-25-4
1-(2-chloro-1,1,2-trifluoro-ethyl)-piperidine

: 321-77-7
fluorochloromethyl piperidino ketone

Guidance literature:: With isopropyl alcohol;
DOI:10.1021/ja01123a048

Reference yield:

: 321-77-7
fluorochloromethyl piperidino ketone

Guidance literature:: N-(Chlor-trifluorvinyl)-piperidin, H2SO4;

Reference yield:

: 321-77-7
fluorochloromethyl piperidino ketone

: 116576-40-0
3-p-chlorophenyl-1-(N-piperidinyl)-2-propen-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / NaI / acetone / 72 h / Heating

2: 16 percent / triethylarsine / Pd(PPh₃)4 / 24 h / 110 °C

With triethylarsine; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetone;