3-(4-(1-hydroxy-2-(methoxycarbonyl)-1H-indol-6-yl)phenyl)propanoic acid

Base Information

Chemical Name:3-(4-(1-hydroxy-2-(methoxycarbonyl)-1H-indol-6-yl)phenyl)propanoic acid
CAS No.:1303576-38-6
Molecular Formula:C₁₉H₁₇NO₅
Molecular Weight:339.348
Hs Code.:

Synonyms:3-(4-(1-hydroxy-2-(methoxycarbonyl)-1H-indol-6-yl)phenyl)propanoic acid

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Chemical Property of 3-(4-(1-hydroxy-2-(methoxycarbonyl)-1H-indol-6-yl)phenyl)propanoic acid

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Technology Process of 3-(4-(1-hydroxy-2-(methoxycarbonyl)-1H-indol-6-yl)phenyl)propanoic acid

There total 4 articles about 3-(4-(1-hydroxy-2-(methoxycarbonyl)-1H-indol-6-yl)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1303574-75-5
C₁₉H₁₇NO₇

: 1303576-38-6
3-(4-(1-hydroxy-2-(methoxycarbonyl)-1H-indol-6-yl)phenyl)propanoic acid

Guidance literature:: With sodium hypophosphite monohydrate; palladium 10% on activated carbon; In tetrahydrofuran; water; at 20 ℃; for 24h;
DOI:10.1016/j.ejmech.2011.08.046

Reference yield:

: 1303573-09-2
3-(4'-methyl-3'-nitrobiphenyl-4-yl)propanoic acid

: 1303576-38-6
3-(4-(1-hydroxy-2-(methoxycarbonyl)-1H-indol-6-yl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / -15 - 20 °C / Inert atmosphere

1.2: Cooling with ice

2.1: palladium 10% on activated carbon; sodium hypophosphite monohydrate / tetrahydrofuran; water / 24 h / 20 °C

With sodium hypophosphite monohydrate; palladium 10% on activated carbon; sodium hydride; In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.ejmech.2011.08.046

Reference yield:

: 60956-26-5
4-bromo-2-nitrotoluene

: 1303576-38-6
3-(4-(1-hydroxy-2-(methoxycarbonyl)-1H-indol-6-yl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium diacetate; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 24 h / 100 °C / Inert atmosphere; Sealed vessel

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / -15 - 20 °C / Inert atmosphere

2.2: Cooling with ice

3.1: palladium 10% on activated carbon; sodium hypophosphite monohydrate / tetrahydrofuran; water / 24 h / 20 °C

With sodium hypophosphite monohydrate; palladium 10% on activated carbon; palladium diacetate; sodium hydride; sodium carbonate; triphenylphosphine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; mineral oil; 1.1: Suzuki coupling;
DOI:10.1016/j.ejmech.2011.08.046