1,1-dimethylethyl (S)-2,2-dimethyl-4-[(3-nitrophenoxy)methyl]-3-oxazolidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl (S)-2,2-dimethyl-4-[(3-nitrophenoxy)methyl]-3-oxazolidinecarboxylate
CAS No.:1384844-41-0
Molecular Formula:C₁₇H₂₄N₂O₆
Molecular Weight:352.387
Hs Code.:

Synonyms:1,1-dimethylethyl (S)-2,2-dimethyl-4-[(3-nitrophenoxy)methyl]-3-oxazolidinecarboxylate

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Chemical Property of 1,1-dimethylethyl (S)-2,2-dimethyl-4-[(3-nitrophenoxy)methyl]-3-oxazolidinecarboxylate

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Technology Process of 1,1-dimethylethyl (S)-2,2-dimethyl-4-[(3-nitrophenoxy)methyl]-3-oxazolidinecarboxylate

There total 2 articles about 1,1-dimethylethyl (S)-2,2-dimethyl-4-[(3-nitrophenoxy)methyl]-3-oxazolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 554-84-7
meta-nitrophenol

: 108149-63-9,108149-65-1
tert-butyl (4S)-4-(hydroxymethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

: 1384844-41-0
1,1-dimethylethyl (S)-2,2-dimethyl-4-[(3-nitrophenoxy)methyl]-3-oxazolidinecarboxylate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In toluene; at 20 - 80 ℃; for 7h; Inert atmosphere;
DOI:10.1016/j.lfs.2011.09.012

Reference yield:

: 95715-85-8
2-(tert-butoxycarbonylamino)-3-hydroxypropionic acid methyl ester

: 1384844-41-0
1,1-dimethylethyl (S)-2,2-dimethyl-4-[(3-nitrophenoxy)methyl]-3-oxazolidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: boron trifluoride diethyl etherate / acetone

2: sodium tetrahydroborate / methanol; tetrahydrofuran / 0 °C / Reflux

3: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 80 °C

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; boron trifluoride diethyl etherate; triphenylphosphine; In tetrahydrofuran; methanol; acetone; toluene;
DOI:10.1016/j.ejmech.2017.06.022

Reference yield:

: 1384844-41-0
1,1-dimethylethyl (S)-2,2-dimethyl-4-[(3-nitrophenoxy)methyl]-3-oxazolidinecarboxylate

: C₁₇H₂₆N₂O₄

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃; for 2.5h;
DOI:10.1016/j.ejmech.2017.06.022