methyl N-<4-(N-3-cyclohexyl-1-ethylthioprop-2-ylaminomethyl)-2-(2-methylphenyl)benzoyl>amino-4-methylsulfonylbutanoate

Base Information

Chemical Name:methyl N-<4-(N-3-cyclohexyl-1-ethylthioprop-2-ylaminomethyl)-2-(2-methylphenyl)benzoyl>amino-4-methylsulfonylbutanoate
CAS No.:216239-61-1
Molecular Formula:C₃₂H₄₆N₂O₅S₂
Molecular Weight:602.86
Hs Code.:

Synonyms:methyl N-<4-(N-3-cyclohexyl-1-ethylthioprop-2-ylaminomethyl)-2-(2-methylphenyl)benzoyl>amino-4-methylsulfonylbutanoate

Suppliers and Price of methyl N-<4-(N-3-cyclohexyl-1-ethylthioprop-2-ylaminomethyl)-2-(2-methylphenyl)benzoyl>amino-4-methylsulfonylbutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl N-<4-(N-3-cyclohexyl-1-ethylthioprop-2-ylaminomethyl)-2-(2-methylphenyl)benzoyl>amino-4-methylsulfonylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl N-<4-(N-3-cyclohexyl-1-ethylthioprop-2-ylaminomethyl)-2-(2-methylphenyl)benzoyl>amino-4-methylsulfonylbutanoate

There total 8 articles about methyl N-<4-(N-3-cyclohexyl-1-ethylthioprop-2-ylaminomethyl)-2-(2-methylphenyl)benzoyl>amino-4-methylsulfonylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 216316-93-7
2(S)-3-cyclohexyl-1-ethylthio-2-propylamine

: 216239-60-0
methyl N-<4-formyl-2-(2-methylphenyl)benzoyl>-2-amino-4-methylsulfonylbutanoate

: 216239-61-1
methyl N-<4-(N-3-cyclohexyl-1-ethylthioprop-2-ylaminomethyl)-2-(2-methylphenyl)benzoyl>amino-4-methylsulfonylbutanoate

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 18h;
DOI:10.1021/jm990335v

Reference yield:

: 103322-56-1
tert-butyl [(1S)-2-cyclohexyl-1-(hydroxymethyl)ethyl]carbamate

: 216239-61-1
methyl N-<4-(N-3-cyclohexyl-1-ethylthioprop-2-ylaminomethyl)-2-(2-methylphenyl)benzoyl>amino-4-methylsulfonylbutanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 67 percent / Et₃N / tetrahydrofuran / 0.5 h

2.1: NaH / tetrahydrofuran / 0.25 h

2.2: tetrahydrofuran / 1 h / Heating

3.1: TFA / CH₂Cl₂ / 0.5 h

4.1: 89 percent / NaBH(OAc)3 / 1,2-dichloro-ethane / 18 h / 20 °C

With sodium tris(acetoxy)borohydride; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; 1.1: mesylation / 2.1: Metallation / 2.2: Substitution / 3.1: acidolysis / 4.1: reductive amination;
DOI:10.1021/jm990335v

Reference yield:

: 117160-99-3
(2S)-2-amino-3-cyclohexylpropan-1-ol hydrochloride

: 216239-61-1
methyl N-<4-(N-3-cyclohexyl-1-ethylthioprop-2-ylaminomethyl)-2-(2-methylphenyl)benzoyl>amino-4-methylsulfonylbutanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisopropylethylamine / dioxane; H₂O / 18 h / 20 °C

2.1: 67 percent / Et₃N / tetrahydrofuran / 0.5 h

3.1: NaH / tetrahydrofuran / 0.25 h

3.2: tetrahydrofuran / 1 h / Heating

4.1: TFA / CH₂Cl₂ / 0.5 h

5.1: 89 percent / NaBH(OAc)3 / 1,2-dichloro-ethane / 18 h / 20 °C

With sodium tris(acetoxy)borohydride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; 1.1: Acylation / 2.1: mesylation / 3.1: Metallation / 3.2: Substitution / 4.1: acidolysis / 5.1: reductive amination;
DOI:10.1021/jm990335v