(3R)-3-{[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]carbonyl}-5-tert-butoxy-5-oxopentanoic acid

Base Information

Chemical Name:(3R)-3-{[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]carbonyl}-5-tert-butoxy-5-oxopentanoic acid
CAS No.:865704-52-5
Molecular Formula:C₂₀H₂₅NO₇
Molecular Weight:391.421
Hs Code.:

Synonyms:(3R)-3-{[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]carbonyl}-5-tert-butoxy-5-oxopentanoic acid

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Chemical Property of (3R)-3-{[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]carbonyl}-5-tert-butoxy-5-oxopentanoic acid

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Technology Process of (3R)-3-{[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]carbonyl}-5-tert-butoxy-5-oxopentanoic acid

There total 4 articles about (3R)-3-{[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]carbonyl}-5-tert-butoxy-5-oxopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 865704-48-9
1-benzyl 5-tert-butyl (3R)-3-{[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]carbonyl}pentanedioate

: 865704-52-5
(3R)-3-{[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]carbonyl}-5-tert-butoxy-5-oxopentanoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; under 760 Torr;
DOI:10.1055/s-2005-865362

Reference yield:

: 865704-45-6
4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-4-oxobutanoic acid

: 865704-52-5
(3R)-3-{[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]carbonyl}-5-tert-butoxy-5-oxopentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 50 percent / P₂O₅ / CHCl₃ / 60 h / 20 °C

2.1: NaI; NaHMDS / tetrahydrofuran / 1 h / -78 °C

2.2: 60 percent / tetrahydrofuran / 4 h / -95 - -75 °C

3.1: 100 percent / H₂ / Pd/C / ethyl acetate / 20 °C / 760 Torr

With hydrogen; sodium hexamethyldisilazane; phosphorus pentoxide; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; chloroform; ethyl acetate;
DOI:10.1055/s-2005-865362

Reference yield:

: 865704-46-7
tert-butyl 4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-4-oxobutanoate

: 865704-52-5
(3R)-3-{[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]carbonyl}-5-tert-butoxy-5-oxopentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaI; NaHMDS / tetrahydrofuran / 1 h / -78 °C

1.2: 60 percent / tetrahydrofuran / 4 h / -95 - -75 °C

2.1: 100 percent / H₂ / Pd/C / ethyl acetate / 20 °C / 760 Torr

With hydrogen; sodium hexamethyldisilazane; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1055/s-2005-865362