N-DesMethyl ent-Tadalafil

Base Information

Chemical Name:N-DesMethyl ent-Tadalafil
CAS No.:929100-66-3
Molecular Formula:C₂₁H₁₇N₃O₄
Molecular Weight:375.384
Hs Code.:
Mol file:929100-66-3.mol

Synonyms:(6R,12aS)-6-(benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Suppliers and Price of N-DesMethyl ent-Tadalafil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(6R,12aS)-N-Desmethylent-Tadalafil
50mg
$ 990.00

TRC
(6R,12aS)-N-Desmethylent-Tadalafil
5mg
$ 130.00

Medical Isotopes, Inc.
N-Desmethylent-Tadalafil
50 mg
$ 2000.00

Medical Isotopes, Inc.
N-Desmethylent-Tadalafil
5 mg
$ 625.00

Total 7 raw suppliers

Chemical Property of N-DesMethyl ent-Tadalafil

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

(6R,12aS)-N-Desmethylent-Tadalafil ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (6R,12aS)-N-Desmethyl Tadalafil (Tadalafil EP Impurity A N-Desmethyl Impurity) is an intermediate in the synthesis of novel potent arylated analogues of tadalafil (T004500).

Technology Process of N-DesMethyl ent-Tadalafil

There total 4 articles about N-DesMethyl ent-Tadalafil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 629652-44-4
(1R,3S)-1-benzo[1,3]dioxol-5-yl-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester

: 929100-66-3
(6R,12aS)-6-(benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Guidance literature:: With ammonia; In methanol; at 45 ℃; for 20h;
DOI:10.1016/j.bmcl.2006.10.069

Reference yield:

: 120-57-0,30024-74-9
piperonal

: 929100-66-3
(6R,12aS)-6-(benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 27 percent / trifluoroacetic acid / CH₂Cl₂ / 24 h / 20 °C

2: 66 percent / triethylamine / CHCl₃ / -10 °C

3: 60 percent / NH₃ / methanol / 20 h / 45 °C

With ammonia; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; chloroform; 1: Pictet-Spengler reaction;
DOI:10.1016/j.bmcl.2006.10.069

Reference yield:

: 7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8
(S)-tryptophan methyl ester hydrochloride

: 929100-66-3
(6R,12aS)-6-(benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 27 percent / trifluoroacetic acid / CH₂Cl₂ / 24 h / 20 °C

2: 66 percent / triethylamine / CHCl₃ / -10 °C

3: 60 percent / NH₃ / methanol / 20 h / 45 °C

With ammonia; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; chloroform; 1: Pictet-Spengler reaction;
DOI:10.1016/j.bmcl.2006.10.069