biphenyl-2-ylcarbamic acid 1-{9-[(R)-2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)ethylamino]nonyl}piperidin-4-yl ester

Base Information

Chemical Name:biphenyl-2-ylcarbamic acid 1-{9-[(R)-2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)ethylamino]nonyl}piperidin-4-yl ester
CAS No.:743460-72-2
Molecular Formula:C₃₆H₄₉N₃O₅
Molecular Weight:603.802
Hs Code.:

Synonyms:biphenyl-2-ylcarbamic acid 1-{9-[(R)-2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)ethylamino]nonyl}piperidin-4-yl ester

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Chemical Property of biphenyl-2-ylcarbamic acid 1-{9-[(R)-2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)ethylamino]nonyl}piperidin-4-yl ester

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Technology Process of biphenyl-2-ylcarbamic acid 1-{9-[(R)-2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)ethylamino]nonyl}piperidin-4-yl ester

There total 10 articles about biphenyl-2-ylcarbamic acid 1-{9-[(R)-2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)ethylamino]nonyl}piperidin-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17337-13-2
[1,1'-biphenyl]-2-yl-isocyanate

: 743460-72-2
biphenyl-2-ylcarbamic acid 1-{9-[(R)-2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)ethylamino]nonyl}piperidin-4-yl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 70 °C / neat (no solvent)

2: 10% palladium on activated charcoal; ammonium bicarbonate / ethanol / 40 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C

4: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

5: sodium tris(acetoxy)borohydride / methanol; dichloromethane

6: 20 % Pd(OH)2/C; hydrogen / ethanol

7: sodium hydrogencarbonate; sodium iodide / tetrahydrofuran / 80 °C

8: triethylamine tris(hydrogen fluoride) / dichloromethane; N,N-dimethyl-formamide

9: water; trifluoroacetic acid / tetrahydrofuran

With 10% palladium on activated charcoal; 20 % Pd(OH)2/C; water; hydrogen; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; ammonium bicarbonate; dimethyl sulfoxide; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.01.043

Reference yield:

: 743460-71-1
C₃₉H₅₃N₃O₅

: 743460-72-2
biphenyl-2-ylcarbamic acid 1-{9-[(R)-2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)ethylamino]nonyl}piperidin-4-yl ester

Guidance literature:: With water; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2011.01.043

Reference yield:

: 852291-44-2
biphenyl-2-ylcarbamic acid 1-(9-hydroxynonyl)piperidin-4-yl ester

: 743460-72-2
biphenyl-2-ylcarbamic acid 1-{9-[(R)-2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)ethylamino]nonyl}piperidin-4-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

2: sodium tris(acetoxy)borohydride / methanol; dichloromethane

3: 20 % Pd(OH)2/C; hydrogen / ethanol

4: sodium hydrogencarbonate; sodium iodide / tetrahydrofuran / 80 °C

5: triethylamine tris(hydrogen fluoride) / dichloromethane; N,N-dimethyl-formamide

6: water; trifluoroacetic acid / tetrahydrofuran

With 20 % Pd(OH)2/C; water; hydrogen; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.01.043