4-(4-FLUOROPHENYL)-3-PIPERIDINEMETHANOL

Base Information

• Chemical Name: 4-(4-FLUOROPHENYL)-3-PIPERIDINEMETHANOL
• CAS No.: 216690-19-6
• Molecular Formula: C12H16 F N O
• Molecular Weight: 209.264
• Mol file: 216690-19-6.mol

Synonyms:4-(4-FLUOROPHENYL)-3-PIPERIDINEMETHANOL

Chemical Property of 4-(4-FLUOROPHENYL)-3-PIPERIDINEMETHANOL

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.514
• Boiling Point: 327.2°Cat760mmHg
• PKA: 14.93±0.10(Predicted)
• Flash Point: 151.7°C
• PSA: 32.26000
• Density: 1.104g/cm³
• LogP: 1.83990

Purity/Quality:

97% ^*data from raw suppliers

4-(4-Fluorophenyl)-3-piperidinemethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(4-Fluorophenyl)-3-piperidinemethanol is a reagent in the preparation of pyrimidine derivatives as inhibitors of cytokines in the treatment of immunologocal diseases.

Technology Process of 4-(4-FLUOROPHENYL)-3-PIPERIDINEMETHANOL

There total 4 articles about 4-(4-FLUOROPHENYL)-3-PIPERIDINEMETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

→ (3RS,4SR)-[4-(4-fluoro-phenyl)-piperidin-3-yl]-methanol (216690-19-6,188869-26-3)

Guidance literature:

Reference yield: 62.0%

(+/-)-trans-4-(4'-fluorophenyl)-3-ethoxycarbonyl-piperidin-2-one → (3RS,4SR)-[4-(4-fluoro-phenyl)-piperidin-3-yl]-methanol (216690-19-6,188869-26-3)

Guidance literature:

With sodium hydroxide; sulfuric acid; In tetrahydrofuran;

Reference yield: 22.0%

trans-3-ethoxycarbonyl-4(4'-fluorophenyl)piperidin-2,6-dione (391937-08-9) → (3RS,4SR)-[4-(4-fluoro-phenyl)-piperidin-3-yl]-methanol (216690-19-6,188869-26-3)

Guidance literature:

In tetrahydrofuran;

upstream raw materials:

(3RS,4SR)-[1-benzyl-4-(4-fluoro-phenyl)-piperidin-3-yl]-methanol

trans-3-ethoxycarbonyl-4(4'-fluorophenyl)piperidin-2,6-dione

Downstream raw materials:

trans-4-(4'-Fluorophenyl)-3-hydroxymethyl-N-methyl piperidine