(R,S)-5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic acid

Base Information

Chemical Name:(R,S)-5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic acid
CAS No.:306776-79-4
Molecular Formula:C₃₅H₆₄N₄O₁₀
Molecular Weight:700.914
Hs Code.:

Synonyms:(R,S)-5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic acid

Suppliers and Price of (R,S)-5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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TRC
5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoicAcid
100mg
$ 945.00

Total 10 raw suppliers

Chemical Property of (R,S)-5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic acid

Chemical Property:

Boiling Point:710.3±60.0 °C(Predicted)
Density:1.081±0.06 g/cm3(Predicted)

Purity/Quality:

>98% ^*data from raw suppliers

5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoicAcid ^*data from reagent suppliers

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Uses 5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic Acid has been used in synthesis of; GdDOTAGA(C18)2: an efficient amphiphilic Gd(III) chelate for the preparation of self-assembled high relaxivity MRI nanoprobes; bifunctional prochelators for coupling to bioactive peptides for radiometal labeling; DOTAGA-anhydride, building block for prepn. of DOTA-like chelating agents.

Technology Process of (R,S)-5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic acid

There total 15 articles about (R,S)-5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.6%

: 306776-78-3
1-(1-carbobenzyloxy-3-carbotertbutoxypropyl)-4,7,10-(carbotertbutoxymethyl)-1,4,7,10-tetraazacyclododecane

: 306776-79-4
(R,S)-5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; water; for 48h;
DOI:10.1016/S0960-894X(00)00413-3

Reference yield: 81.0%

: 1-(tert-butyl) 5-methyl 2-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanedioate

: 306776-79-4
(R,S)-5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic acid

Guidance literature:: With sodium hydroxide; In methanol; at 50 ℃;
DOI:10.1002/chem.201904757

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 306776-79-4
(R,S)-5-(tert-butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / K₂CO₃ / acetonitrile / 18 h / 20 °C

2: 84.6 percent / H₂ / Pd/C / methanol; H₂O / 48 h

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; water; acetonitrile; 1: Alkylation / 2: Hydrogenolysis;
DOI:10.1016/S0960-894X(00)00413-3