Technology Process of C18H10ClNO
There total 10 articles about C18H10ClNO which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
thionyl chloride; N,N-dimethyl-formamide;
In
dichloromethane;
for 3h;
Reflux;
DOI:10.1016/j.bmcl.2010.12.110
- Guidance literature:
-
Multi-step reaction with 7 steps
1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 3 h / Reflux
2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
3: palladium 10% on activated carbon; hydrogen / ethanol / 15 h / 2585.81 Torr
4: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere
5: tetrakis(triphenylphosphine) palladium(0); potassium fluoride dihydrate / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere
6: water; sodium hydroxide / ethanol / 3 h
7: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 3 h / Reflux
With
pyridine; tetrakis(triphenylphosphine) palladium(0); thionyl chloride; potassium fluoride dihydrate; palladium 10% on activated carbon; water; hydrogen; triethylamine; N,N-dimethyl-formamide; sodium hydroxide;
In
1,2-dimethoxyethane; ethanol; dichloromethane; water;
5: Suzuki coupling;
DOI:10.1016/j.bmcl.2010.12.110
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / ethanol / 15 h / 2585.81 Torr
3: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere
4: tetrakis(triphenylphosphine) palladium(0); potassium fluoride dihydrate / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere
5: water; sodium hydroxide / ethanol / 3 h
6: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 3 h / Reflux
With
pyridine; tetrakis(triphenylphosphine) palladium(0); thionyl chloride; potassium fluoride dihydrate; palladium 10% on activated carbon; water; hydrogen; triethylamine; N,N-dimethyl-formamide; sodium hydroxide;
In
1,2-dimethoxyethane; ethanol; dichloromethane; water;
4: Suzuki coupling;
DOI:10.1016/j.bmcl.2010.12.110
