2-<(S)-1-allyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonyl-(R)-Δ2-thiazoline

Base Information

Chemical Name:2-<(S)-1-allyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonyl-(R)-Δ2-thiazoline
CAS No.:132402-65-4
Molecular Formula:C₁₇H₂₀N₂O₄S
Molecular Weight:348.423
Hs Code.:

Synonyms:2-<(S)-1-allyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonyl-(R)-Δ2-thiazoline

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Chemical Property of 2-<(S)-1-allyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonyl-(R)-Δ2-thiazoline

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Technology Process of 2-<(S)-1-allyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonyl-(R)-Δ2-thiazoline

There total 5 articles about 2-<(S)-1-allyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonyl-(R)-Δ2-thiazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1452389-59-1
alloc-L-Phe-L-Cys(Trt)-OMe

: 132402-65-4
2-<(S)-1-allyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonyl-(R)-Δ2-thiazoline

Guidance literature:: With trifluoromethylsulfonic anhydride; Triphenylphosphine oxide; In dichloromethane; at -20 - 0 ℃; for 2.75h; Inert atmosphere;
DOI:10.1002/anie.201302372

Reference yield: 20.0%

: 18598-63-5
L-cysteine methyl ester hydrochloride

: 132402-58-5
2-allyloxycarbonylamino-3-phenyl-(S)-propioimino ethyl ether

: 132402-65-4
2-<(S)-1-allyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonyl-(R)-Δ2-thiazoline

Guidance literature:: In ethanol; for 2h; Ambient temperature;
DOI:10.1016/S0040-4020(01)81482-4

Reference yield:

: 90508-20-6
N-allyloxycarbonyl-(S)-phenylalanate

: 132402-65-4
2-<(S)-1-allyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonyl-(R)-Δ2-thiazoline

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / acetyl chloride / Ambient temperature

2: 99 percent / NH₃ / methanol / Ambient temperature

3: 97 percent / CH₂Cl₂ / Ambient temperature

4: 20 percent / ethanol / 2 h / Ambient temperature

With ammonia; acetyl chloride; In methanol; ethanol; dichloromethane;
DOI:10.1016/S0040-4020(01)81482-4