N-[5-amino-2-(3(R)-amino-1-piperidinyl)phenyl]-2-[1-(2-thienylmethyl)-1H-pyrazol-4-yl]-4-thiazolecarboxamide

Base Information

Chemical Name:N-[5-amino-2-(3(R)-amino-1-piperidinyl)phenyl]-2-[1-(2-thienylmethyl)-1H-pyrazol-4-yl]-4-thiazolecarboxamide
CAS No.:1365172-69-5
Molecular Formula:C₂₃H₂₅N₇OS₂
Molecular Weight:479.63
Hs Code.:

Synonyms:N-[5-amino-2-(3(R)-amino-1-piperidinyl)phenyl]-2-[1-(2-thienylmethyl)-1H-pyrazol-4-yl]-4-thiazolecarboxamide

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Chemical Property of N-[5-amino-2-(3(R)-amino-1-piperidinyl)phenyl]-2-[1-(2-thienylmethyl)-1H-pyrazol-4-yl]-4-thiazolecarboxamide

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Technology Process of N-[5-amino-2-(3(R)-amino-1-piperidinyl)phenyl]-2-[1-(2-thienylmethyl)-1H-pyrazol-4-yl]-4-thiazolecarboxamide

There total 6 articles about N-[5-amino-2-(3(R)-amino-1-piperidinyl)phenyl]-2-[1-(2-thienylmethyl)-1H-pyrazol-4-yl]-4-thiazolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365174-61-3
C₃₃H₄₁N₇O₅S₂

: 1365172-69-5
N-[5-amino-2-(3(R)-amino-1-piperidinyl)phenyl]-2-[1-(2-thienylmethyl)-1H-pyrazol-4-yl]-4-thiazolecarboxamide

Guidance literature:: C₃₃H₄₁N₇O₅S₂; With trifluoroacetic acid; at 20 ℃; for 1h;

With ammonia; In methanol; dichloromethane;

Reference yield:

: 364-76-1
4-Fluoro-3-nitroaniline

: 1365172-69-5
N-[5-amino-2-(3(R)-amino-1-piperidinyl)phenyl]-2-[1-(2-thienylmethyl)-1H-pyrazol-4-yl]-4-thiazolecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 168 h

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 80 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

5: water; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 1 h / 110 °C / Microwave irradiation; Inert atmosphere

6: trifluoroacetic acid / 1 h / 20 °C

With water; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; ethanol; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 332370-72-6
N-(tert-butoxycarbonyl)-4-fluoro-3-nitroaniline

: 1365172-69-5
N-[5-amino-2-(3(R)-amino-1-piperidinyl)phenyl]-2-[1-(2-thienylmethyl)-1H-pyrazol-4-yl]-4-thiazolecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 80 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

4: water; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 1 h / 110 °C / Microwave irradiation; Inert atmosphere

5: trifluoroacetic acid / 1 h / 20 °C

With water; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; ethanol; N,N-dimethyl-formamide; toluene; acetonitrile;