N-{3-[2-(chloromethyl)-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl]propyl}-N'-cyclohexylurea

Base Information

Chemical Name:N-{3-[2-(chloromethyl)-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl]propyl}-N'-cyclohexylurea
CAS No.:852802-09-6
Molecular Formula:C₂₀H₂₅ClN₆O
Molecular Weight:400.911
Hs Code.:

Synonyms:N-{3-[2-(chloromethyl)-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl]propyl}-N'-cyclohexylurea

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Chemical Property of N-{3-[2-(chloromethyl)-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl]propyl}-N'-cyclohexylurea

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Technology Process of N-{3-[2-(chloromethyl)-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl]propyl}-N'-cyclohexylurea

There total 5 articles about N-{3-[2-(chloromethyl)-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl]propyl}-N'-cyclohexylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-[2-(chloromethyl)-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl]propan-1-amine hydrochloride

: 3173-53-3
Cyclohexyl isocyanate

: 852802-09-6
N-{3-[2-(chloromethyl)-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl]propyl}-N'-cyclohexylurea

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 852802-03-0
tert-butyl 3-[(3-nitro[1,5]naphthyridin-4-yl)amino]propylcarbamate

: 852802-09-6
N-{3-[2-(chloromethyl)-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl]propyl}-N'-cyclohexylurea

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / 5 % platinum on carbon / ethyl acetate / 2 h / 1551.49 Torr

2: dichloromethane / 1 h / 0 - 20 °C

3: potassium carbonate / ethanol; water / 20 - 40 °C

4: hydrogenchloride / methanol; water / 72 h / 20 °C

5: triethylamine / dichloromethane / 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; triethylamine; 5 % platinum on carbon; In methanol; ethanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 85967-19-7
4-chloro-3-nitro-[1,5]naphthyridine

: 852802-09-6
N-{3-[2-(chloromethyl)-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl]propyl}-N'-cyclohexylurea

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 3 h / 20 °C

2: hydrogen / 5 % platinum on carbon / ethyl acetate / 2 h / 1551.49 Torr

3: dichloromethane / 1 h / 0 - 20 °C

4: potassium carbonate / ethanol; water / 20 - 40 °C

5: hydrogenchloride / methanol; water / 72 h / 20 °C

6: triethylamine / dichloromethane / 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; triethylamine; 5 % platinum on carbon; In methanol; ethanol; dichloromethane; water; ethyl acetate;