methyl (2E)-3-(3-{2-[(3-chloro-4-fluorophenyl)amino]-2-oxoethoxy}-4-methoxyphenyl)acrylate

Base Information

Chemical Name:methyl (2E)-3-(3-{2-[(3-chloro-4-fluorophenyl)amino]-2-oxoethoxy}-4-methoxyphenyl)acrylate
CAS No.:1607457-34-0
Molecular Formula:C₁₉H₁₇ClFNO₅
Molecular Weight:393.799
Hs Code.:

Synonyms:methyl (2E)-3-(3-{2-[(3-chloro-4-fluorophenyl)amino]-2-oxoethoxy}-4-methoxyphenyl)acrylate

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Chemical Property of methyl (2E)-3-(3-{2-[(3-chloro-4-fluorophenyl)amino]-2-oxoethoxy}-4-methoxyphenyl)acrylate

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Technology Process of methyl (2E)-3-(3-{2-[(3-chloro-4-fluorophenyl)amino]-2-oxoethoxy}-4-methoxyphenyl)acrylate

There total 3 articles about methyl (2E)-3-(3-{2-[(3-chloro-4-fluorophenyl)amino]-2-oxoethoxy}-4-methoxyphenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 97966-29-5
methyl (E)-3-(3-hydroxy-4-methoxyphenyl)-2-propenoate

: 96980-64-2
N-(2-chloroacetyl)-3-chloro-4-fluoroaniline

: 1607457-34-0
methyl (2E)-3-(3-{2-[(3-chloro-4-fluorophenyl)amino]-2-oxoethoxy}-4-methoxyphenyl)acrylate

Guidance literature:: methyl (E)-3-(3-hydroxy-4-methoxyphenyl)-2-propenoate; With potassium carbonate; In acetone; at 20 ℃; for 0.5h; Inert atmosphere;

N-(2-chloroacetyl)-3-chloro-4-fluoroaniline; In acetone; for 10h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2014.03.019

Reference yield:

: 537-73-5
trans-3-hydroxy-4-methoxycinnamic acid

: 1607457-34-0
methyl (2E)-3-(3-{2-[(3-chloro-4-fluorophenyl)amino]-2-oxoethoxy}-4-methoxyphenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / 4 h / Reflux; Inert atmosphere

2.1: potassium carbonate / acetone / 0.5 h / 20 °C / Inert atmosphere

2.2: 10 h / Inert atmosphere; Reflux

With sulfuric acid; potassium carbonate; In acetone;
DOI:10.1016/j.bmc.2014.03.019

Reference yield:

: 621-59-0
isovanillin

: 1607457-34-0
methyl (2E)-3-(3-{2-[(3-chloro-4-fluorophenyl)amino]-2-oxoethoxy}-4-methoxyphenyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene / 4 h / Reflux; Inert atmosphere

2.1: sulfuric acid / 4 h / Reflux; Inert atmosphere

3.1: potassium carbonate / acetone / 0.5 h / 20 °C / Inert atmosphere

3.2: 10 h / Inert atmosphere; Reflux

With pyridine; sulfuric acid; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetone; 1.1: |Knoevenagel Condensation;
DOI:10.1016/j.bmc.2014.03.019