(S)-3-(2-(2-chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid

Base Information

Chemical Name:(S)-3-(2-(2-chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid
CAS No.:1322598-34-4
Molecular Formula:C₁₉H₁₇ClF₃NO₃
Molecular Weight:399.797
Hs Code.:

Synonyms:(S)-3-(2-(2-chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid

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Chemical Property of (S)-3-(2-(2-chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid

Chemical Property:

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Technology Process of (S)-3-(2-(2-chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid

There total 8 articles about (S)-3-(2-(2-chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: C₂₀H₁₉ClF₃NO₃

: 1322598-34-4
(S)-3-(2-(2-chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1002/cmdc.202100356

Reference yield:

: dimethyl 2-((S)-1-(((S)-tert-butylsulfinyl)amino)-2-(4-(trifluoromethyl)phenyl)ethyl)malonate

: 1322598-34-4
(S)-3-(2-(2-chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; water / 3 h / 110 °C

1.2: 110 °C

2.1: benzotriazol-1-ol; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3.5 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: water; lithium hydroxide / tetrahydrofuran / 0 - 20 °C

With hydrogenchloride; dmap; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1002/cmdc.202100356

Reference yield:

: 2968-93-6
2-(4-trifluoromethylphenyl)ethanol

: 1322598-34-4
(S)-3-(2-(2-chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 3.5 h / 20 - 70 °C

2.1: pyridinium p-toluenesulfonate / dichloromethane / Darkness

3.1: sodium iodide / 48 h / Inert atmosphere; Darkness

4.1: hydrogenchloride; water / 3 h / 110 °C

4.2: 110 °C

5.1: benzotriazol-1-ol; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3.5 h / 0 °C / Inert atmosphere

5.2: 0 - 20 °C / Inert atmosphere

6.1: water; lithium hydroxide / tetrahydrofuran / 0 - 20 °C

With hydrogenchloride; dmap; water; pyridinium p-toluenesulfonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium iodide; lithium hydroxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1002/cmdc.202100356