(2R)-N-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)-phenyl)pyrrolidine-2-carboxamide

Base Information

Chemical Name:(2R)-N-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)-phenyl)pyrrolidine-2-carboxamide
CAS No.:911417-38-4
Molecular Formula:C₂₆H₂₃N₇O
Molecular Weight:449.515
Hs Code.:

Synonyms:(2R)-N-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)-phenyl)pyrrolidine-2-carboxamide

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Chemical Property of (2R)-N-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)-phenyl)pyrrolidine-2-carboxamide

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Technology Process of (2R)-N-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)-phenyl)pyrrolidine-2-carboxamide

There total 10 articles about (2R)-N-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)-phenyl)pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 911417-37-3
tert-butyl 5-(2-(3-((R)-pyrrolidine-2-carboxamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

: 911417-38-4
(2R)-N-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)-phenyl)pyrrolidine-2-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 100.0%

: C₂₈H₂₂F₃N₇O₃

: 911417-38-4
(2R)-N-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)-phenyl)pyrrolidine-2-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 911417-27-1
tert-butyl 5-(2-(3-nitrophenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

: 911417-38-4
(2R)-N-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)-phenyl)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / methanol; 1,2-dimethoxyethane / 16 h / 20 °C

2: triethylamine / dmap / dichloromethane / 18 h / 20 °C

3: methanol; water; potassium carbonate / 2 h / Heating / reflux

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With methanol; water; hydrogen; potassium carbonate; triethylamine; trifluoroacetic acid; dmap; palladium 10% on activated carbon; In methanol; 1,2-dimethoxyethane; dichloromethane;