(E,4R,5S)-6-ethyl 1-methyl 5-(4-methoxyphenylamino)-4-(benzyloxy)hex-2-enodioate

Base Information

Chemical Name:(E,4R,5S)-6-ethyl 1-methyl 5-(4-methoxyphenylamino)-4-(benzyloxy)hex-2-enodioate
CAS No.:880548-33-4
Molecular Formula:C₂₃H₂₇NO₆
Molecular Weight:413.47
Hs Code.:

Synonyms:(E,4R,5S)-6-ethyl 1-methyl 5-(4-methoxyphenylamino)-4-(benzyloxy)hex-2-enodioate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E,4R,5S)-6-ethyl 1-methyl 5-(4-methoxyphenylamino)-4-(benzyloxy)hex-2-enodioate

Chemical Property:

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Technology Process of (E,4R,5S)-6-ethyl 1-methyl 5-(4-methoxyphenylamino)-4-(benzyloxy)hex-2-enodioate

There total 2 articles about (E,4R,5S)-6-ethyl 1-methyl 5-(4-methoxyphenylamino)-4-(benzyloxy)hex-2-enodioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₃NO₅

: 1067-74-9
Methyl diethylphosphonoacetate

: 880548-33-4
(E,4R,5S)-6-ethyl 1-methyl 5-(4-methoxyphenylamino)-4-(benzyloxy)hex-2-enodioate

: (E)-6-ethyl 1-methyl 5-(4-methoxyphenylamino)-4-(benzyloxy)hex-2-enodioate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium bromide; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;
DOI:10.1039/b516352h

Reference yield:

: 60656-87-3
benzyloxyacetoaldehyde

: 880548-33-4
(E,4R,5S)-6-ethyl 1-methyl 5-(4-methoxyphenylamino)-4-(benzyloxy)hex-2-enodioate

Guidance literature:: Multi-step reaction with 2 steps

1: (S)-proline / dimethylformamide / 48 h / 20 °C

2: LiBr; DBU / dimethylformamide / 1.5 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; L-proline; lithium bromide; In N,N-dimethyl-formamide; 1: Mannich reaction / 2: Horner-Wittig-Emmons reaction;
DOI:10.1039/b516352h