10-hydroxy-8-methyl-3-oxo-3-phenyl-2,4-dihydro-1H-phosphinino[3,4-c]chromen-5-one

Base Information

Chemical Name:10-hydroxy-8-methyl-3-oxo-3-phenyl-2,4-dihydro-1H-phosphinino[3,4-c]chromen-5-one
CAS No.:77217-77-7
Molecular Formula:C₁₉H₁₇O₄P
Molecular Weight:340.315
Hs Code.:
NSC Number:327721
DSSTox Substance ID:DTXSID70419524

Synonyms:77217-77-7;NSC327721;DTXSID70419524;NSC-327721;10-hydroxy-8-methyl-3-oxo-3-phenyl-2,4-dihydro-1H-phosphinino[3,4-c]chromen-5-one

Suppliers and Price of 10-hydroxy-8-methyl-3-oxo-3-phenyl-2,4-dihydro-1H-phosphinino[3,4-c]chromen-5-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 10-hydroxy-8-methyl-3-oxo-3-phenyl-2,4-dihydro-1H-phosphinino[3,4-c]chromen-5-one

Chemical Property:

Vapor Pressure:2.58E-17mmHg at 25°C
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:340.08644602
Heavy Atom Count:24
Complexity:605

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=C2C3=C(CP(=O)(CC3)C4=CC=CC=C4)C(=O)OC2=C1)O

Technology Process of 10-hydroxy-8-methyl-3-oxo-3-phenyl-2,4-dihydro-1H-phosphinino[3,4-c]chromen-5-one

There total 3 articles about 10-hydroxy-8-methyl-3-oxo-3-phenyl-2,4-dihydro-1H-phosphinino[3,4-c]chromen-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6775-11-7
bis(2-(carbomethoxy)ethyl)phenylphosphine

: 77217-77-7
1,2,3,4-tetrahydro-10-hydroxy-8-methyl-3-phenyl-5H-phosphorino<3,4-c><1>benzopyran-5-one 3-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sodium methoxide, 2.) sodium / 1.) toluene, reflux, 2 h, 2.) reflux, 15 h

2: 53 percent / 30percent H₂O₂ / acetone / 0.17 h / 0 °C

3: 1.) conc. H₂SO₄, 2.) Cl₃P=O / 1.) 5 min, 2.) room temperature, 40 h

With sulfuric acid; dihydrogen peroxide; sodium methylate; sodium; trichlorophosphate; In acetone;
DOI:10.1021/ja00398a025

Reference yield:

: 63316-04-1
methyl 4-oxo-1-phenyl-3-phosphorinanecarboxylate

: 77217-77-7
1,2,3,4-tetrahydro-10-hydroxy-8-methyl-3-phenyl-5H-phosphorino<3,4-c><1>benzopyran-5-one 3-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / 30percent H₂O₂ / acetone / 0.17 h / 0 °C

2: 1.) conc. H₂SO₄, 2.) Cl₃P=O / 1.) 5 min, 2.) room temperature, 40 h

With sulfuric acid; dihydrogen peroxide; trichlorophosphate; In acetone;
DOI:10.1021/ja00398a025

Reference yield:

: 504-15-4
orcinol

: 67976-13-0
methyl 4-oxo-1-phenyl-3-phosphorinanecarboxylate 1-oxide

: 77217-77-7
1,2,3,4-tetrahydro-10-hydroxy-8-methyl-3-phenyl-5H-phosphorino<3,4-c><1>benzopyran-5-one 3-oxide

Guidance literature:: With sulfuric acid; trichlorophosphate; Yield given. Multistep reaction; 1.) 5 min, 2.) room temperature, 40 h;
DOI:10.1021/ja00398a025