(1R,9R)-4-methoxy-1,10-dimethyl-11-oxo-10-azatricyclo-[7.2.1.0^2,7]-dodeca-2⁽⁷⁾,3,5-triene

Base Information

• Chemical Name: (1R,9R)-4-methoxy-1,10-dimethyl-11-oxo-10-azatricyclo-[7.2.1.0^2,7]-dodeca-2⁽⁷⁾,3,5-triene
• CAS No.: 873843-78-8
• Molecular Formula: C₁₄H₁₇NO₂
• Molecular Weight: 231.294
• Mol file: 873843-78-8.mol

Synonyms:(1R,9R)-4-methoxy-1,10-dimethyl-11-oxo-10-azatricyclo-[7.2.1.0^2,7]-dodeca-2⁽⁷⁾,3,5-triene

Chemical Property of (1R,9R)-4-methoxy-1,10-dimethyl-11-oxo-10-azatricyclo-[7.2.1.0^2,7]-dodeca-2⁽⁷⁾,3,5-triene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,9R)-4-methoxy-1,10-dimethyl-11-oxo-10-azatricyclo-[7.2.1.0^2,7]-dodeca-2⁽⁷⁾,3,5-triene

There total 1 articles about (1R,9R)-4-methoxy-1,10-dimethyl-11-oxo-10-azatricyclo-[7.2.1.0^2,7]-dodeca-2⁽⁷⁾,3,5-triene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(S)-5-(2-bromo-4-methoxybenzyl)-1-methyl-3-methylenepyrrolidin-2-one (873843-71-1) → (1R,9R)-4-methoxy-1,10-dimethyl-11-oxo-10-azatricyclo-[7.2.1.02,7]-dodeca-2(7),3,5-triene (873843-78-8) + (R)-5-(4-methoxybenzyl)-1,3-dimethyl-1,5-dihydropyrrol-2-one

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 1h; Heating;

DOI:10.1039/b510761j

Reference yield: 93.0%

(1R,9R)-4-methoxy-1,10-dimethyl-11-oxo-10-azatricyclo-[7.2.1.02,7]-dodeca-2(7),3,5-triene (873843-78-8) → (+)-8-O-methylaphanorphine (128524-63-0,791780-36-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1039/b510761j DOI:10.1039/b614999e

upstream raw materials:

(S)-5-(2-bromo-4-methoxybenzyl)-1-methyl-3-methylenepyrrolidin-2-one

Downstream raw materials:

(+)-8-O-methylaphanorphine