evobrutinib

Base Information

Chemical Name:evobrutinib
CAS No.:1415823-73-2
Molecular Formula:C₂₅H₂₇N₅O₂
Molecular Weight:429.522
Hs Code.:
Mol file:1415823-73-2.mol

Synonyms:1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one

Suppliers and Price of evobrutinib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Evobrutinib
10mg
$ 315.00

TRC
Evobrutinib
5mg
$ 190.00

DC Chemicals
Evobrutinib >98%
1 g
$ 2200.00

DC Chemicals
Evobrutinib >98%
100 mg
$ 600.00

Cayman Chemical
Evobrutinib
10mg
$ 221.00

Cayman Chemical
Evobrutinib
1mg
$ 26.00

Cayman Chemical
Evobrutinib
5mg
$ 124.00

Cayman Chemical
Evobrutinib
25mg
$ 455.00

AK Scientific
Evobrutinib
5mg
$ 267.00

ACHEMBLOCK
1-(4-(((6-Amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one 98%
25MG
$ 375.00

Total 14 raw suppliers

Chemical Property of evobrutinib

Chemical Property:

Melting Point:173 - 174oC
Boiling Point:683.4±55.0 °C(Predicted)
PKA:5.29±0.10(Predicted)
Density:1.227±0.06 g/cm3(Predicted)
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

Evobrutinib ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Evobrutinib is a highly selective inhibitor of the Bruton’s tyrosine kinase (BTK), which is important in the -development and functioning of various immune cells including B -lymphocytes and macrophages. Preclinical research suggests it may be therapeutically useful in certain autoimmune diseases.

Technology Process of evobrutinib

There total 3 articles about evobrutinib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1415824-88-2
5-(4-phenoxyphenyl)-N-(piperidin-4-ylmethyl)pyrimidine-4,6-diamine

: 814-68-6,25189-84-8
acryloyl chloride

: 1415823-73-2
1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 0 - 20 ℃;

Reference yield:

: 1415824-87-1
tert-butyl 4-({[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino}-methyl)piperidine-1-carboxylate

: 1415823-73-2
1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / diethyl ether; methanol / 20 °C

2: sodium hydrogencarbonate / water; tetrahydrofuran / 0 - 20 °C

With hydrogenchloride; sodium hydrogencarbonate; In tetrahydrofuran; methanol; diethyl ether; water;

Reference yield:

: 144222-22-0
tert-butyl 4-(aminomethyl)piperidine-1-carboxylate

: 1415823-73-2
1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 17 h / 90 °C

2: potassium carbonate; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 2 h / 150 °C / Microwave irradiation

3: methanol; hydrogenchloride / diethyl ether / 18 h / 20 °C

4: sodium carbonate / water; tetrahydrofuran / 12 h / 0 - 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; hydrogenchloride; methanol; palladium diacetate; sodium carbonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.9b00794