5-(4-nitrophenyl)-6-(1,3-oxazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

Base Information

Chemical Name:5-(4-nitrophenyl)-6-(1,3-oxazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine
CAS No.:871554-20-0
Molecular Formula:C₁₅H₁₀N₆O₃
Molecular Weight:322.283
Hs Code.:

Synonyms:5-(4-nitrophenyl)-6-(1,3-oxazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

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Chemical Property of 5-(4-nitrophenyl)-6-(1,3-oxazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

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Technology Process of 5-(4-nitrophenyl)-6-(1,3-oxazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

There total 8 articles about 5-(4-nitrophenyl)-6-(1,3-oxazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 871553-42-3
4-amino-5-(4-nitrophenyl)pyrrolo[2,1-f][1,2,4]triazine-6-carbaldehyde

: 38622-91-2,36635-61-7
[(p-methylphenyl)sulfonylmethyl]isonitrile

: 871554-20-0
5-(4-nitrophenyl)-6-(1,3-oxazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

Guidance literature:: With potassium carbonate; In methanol; Heating / reflux;

Reference yield:

: 871553-12-7
ethyl 4-amino-5-(4-nitrophenyl)pyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

: 871554-20-0
5-(4-nitrophenyl)-6-(1,3-oxazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2 h / 20 °C

2: Dess-Martin periodane / tetrahydrofuran; dichloromethane / 5 h / 20 °C

3: potassium carbonate / methanol / Heating / reflux

With diisobutylaluminium hydride; potassium carbonate; Dess-Martin periodane; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 871553-17-2
ethyl 5-formyl-4-(4-nitrophenyl)-1H-pyrrole-3-carboxylate

: 871554-20-0
5-(4-nitrophenyl)-6-(1,3-oxazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine; hydroxylamine hydrochloride / 2 h / 20 °C

1.2: 17 h / 80 °C

2.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.25 h / 20 °C

2.2: 17 h / 20 - 80 °C

2.3: 20 °C

3.1: 19 h / 20 - 195 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2 h / 20 °C

5.1: Dess-Martin periodane / tetrahydrofuran; dichloromethane / 5 h / 20 °C

6.1: potassium carbonate / methanol / Heating / reflux

With pyridine; hydroxylamine hydrochloride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; Dess-Martin periodane; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); dichloromethane; toluene;