acetic acid 2-(3-{(R)-(4-{amino[propoxycarbonylimino]methyl}phenylamino)-[5-(2-fluoro-1,1-dimethylethoxycarbonyloxymethoxy)-1-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester

Base Information

Chemical Name:acetic acid 2-(3-{(R)-(4-{amino[propoxycarbonylimino]methyl}phenylamino)-[5-(2-fluoro-1,1-dimethylethoxycarbonyloxymethoxy)-1-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester
CAS No.:1350551-84-6
Molecular Formula:C₃₅H₄₀F₂N₈O₁₀
Molecular Weight:770.747
Hs Code.:

acetic acid 2-(3-{(R)-(4-{amino[propoxycarbonylimino]methyl}phenylamino)-[5-(2-fluoro-1,1-dimethylethoxycarbonyloxymethoxy)-1-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester

Synonyms:acetic acid 2-(3-{(R)-(4-{amino[propoxycarbonylimino]methyl}phenylamino)-[5-(2-fluoro-1,1-dimethylethoxycarbonyloxymethoxy)-1-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester

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Chemical Property of acetic acid 2-(3-{(R)-(4-{amino[propoxycarbonylimino]methyl}phenylamino)-[5-(2-fluoro-1,1-dimethylethoxycarbonyloxymethoxy)-1-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester

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Technology Process of acetic acid 2-(3-{(R)-(4-{amino[propoxycarbonylimino]methyl}phenylamino)-[5-(2-fluoro-1,1-dimethylethoxycarbonyloxymethoxy)-1-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester

There total 22 articles about acetic acid 2-(3-{(R)-(4-{amino[propoxycarbonylimino]methyl}phenylamino)-[5-(2-fluoro-1,1-dimethylethoxycarbonyloxymethoxy)-1-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350552-42-9
acetic acid 2-(3-{(R)-(carbamimidoylphenylamino)-[5-(2-fluoro-1,1-dimethylethoxycarbonyloxymethoxy)-1-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester acetate

: 67036-12-8
n-propyl 4-nitrophenyl carbonate

: 1350551-84-6
acetic acid 2-(3-{(R)-(4-{amino[propoxycarbonylimino]methyl}phenylamino)-[5-(2-fluoro-1,1-dimethylethoxycarbonyloxymethoxy)-1-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester

Guidance literature:: With pyridine; at 20 ℃;

Reference yield:

: 883576-31-6
2-Fluoro-3-hydroxy-5-methoxybenzaldehyde

: 1350551-84-6
acetic acid 2-(3-{(R)-(4-{amino[propoxycarbonylimino]methyl}phenylamino)-[5-(2-fluoro-1,1-dimethylethoxycarbonyloxymethoxy)-1-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester

Guidance literature:: Multi-step reaction with 16 steps

1.1: guanidine hydrochloride / methanol / 1.5 h / 40 °C / Inert atmosphere

1.2: 22 h / 40 °C

2.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 13.5 h / 70 °C / Inert atmosphere

3.1: water; diammonium sulfide / tetrahydrofuran; methanol / 20 °C

4.1: acetonitrile / 0.83 h / 20 °C / Cooling

5.1: 2,4,6-trimethyl-pyridine / ethyl acetate; toluene / 85 °C

6.1: triethylamine / toluene / 4.17 h / 50 - 110 °C

7.1: acetic acid; 2-picoline borane complex / water; methanol / 24 h / 20 °C

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 23.5 h / 20 °C

8.2: 0.33 h

9.1: acetyl chloride; methanol / 18.5 h / 5 - 10 °C

9.2: 18 h / 10 - 20 °C

9.3: 18 h / 20 °C

10.1: triethylamine / methanol / 0.25 h / 60 °C

10.2: 23 h / 0 - 20 °C

11.1: hydrogenchloride / ethanol; water; methanol / 20 °C

12.1: potassium carbonate / dimethyl sulfoxide / 96 h / 20 °C

13.1: triethylamine / dmap / N,N-dimethyl-formamide / 1.33 h / 20 °C

14.1: rubidium carbonate / N,N-dimethyl acetamide / 1 h / 85 °C / Inert atmosphere

15.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 15 h / 45 °C / Inert atmosphere

16.1: pyridine / 20 °C

With rubidium carbonate; pyridine; 2,4,6-trimethyl-pyridine; hydrogenchloride; methanol; diammonium sulfide; 2-picoline borane complex; water; guanidine hydrochloride; potassium carbonate; acetic acid; triethylamine; acetyl chloride; sodium iodide; sodium hydroxide; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl acetamide; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 459-60-9
1-fluoro-4-methoxybenzene

: 1350551-84-6
acetic acid 2-(3-{(R)-(4-{amino[propoxycarbonylimino]methyl}phenylamino)-[5-(2-fluoro-1,1-dimethylethoxycarbonyloxymethoxy)-1-pyrimidin-2-yl-2H-[1,2,4]triazol-3-yl]methyl}-2-fluoro-5-methoxyphenoxy)ethyl ester

Guidance literature:: Multi-step reaction with 19 steps

1.1: n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine / hexane; tetrahydrofuran / -70 °C / Inert atmosphere

1.2: 1 h

1.3: -10 - 20 °C

2.1: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice; Inert atmosphere

3.1: n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine / hexane; tetrahydrofuran / 3 h / -72 - -56 °C / Inert atmosphere

3.3: 10 - 20 °C

4.1: guanidine hydrochloride / methanol / 1.5 h / 40 °C / Inert atmosphere

4.2: 22 h / 40 °C

5.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 13.5 h / 70 °C / Inert atmosphere

6.1: water; diammonium sulfide / tetrahydrofuran; methanol / 20 °C

7.1: acetonitrile / 0.83 h / 20 °C / Cooling

8.1: 2,4,6-trimethyl-pyridine / ethyl acetate; toluene / 85 °C

9.1: triethylamine / toluene / 4.17 h / 50 - 110 °C

10.1: acetic acid; 2-picoline borane complex / water; methanol / 24 h / 20 °C

11.1: sodium hydroxide; water / tetrahydrofuran; methanol / 23.5 h / 20 °C

11.2: 0.33 h

12.1: acetyl chloride; methanol / 18.5 h / 5 - 10 °C

12.2: 18 h / 10 - 20 °C

12.3: 18 h / 20 °C

13.1: triethylamine / methanol / 0.25 h / 60 °C

13.2: 23 h / 0 - 20 °C

14.1: hydrogenchloride / ethanol; water; methanol / 20 °C

15.1: potassium carbonate / dimethyl sulfoxide / 96 h / 20 °C

16.1: triethylamine / dmap / N,N-dimethyl-formamide / 1.33 h / 20 °C

17.1: rubidium carbonate / N,N-dimethyl acetamide / 1 h / 85 °C / Inert atmosphere

18.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 15 h / 45 °C / Inert atmosphere

19.1: pyridine / 20 °C

With rubidium carbonate; pyridine; 2,4,6-trimethyl-pyridine; hydrogenchloride; methanol; diammonium sulfide; n-butyllithium; 2-picoline borane complex; N,N,N',N'',N'''-pentamethyldiethylenetriamine; water; guanidine hydrochloride; potassium carbonate; acetic acid; triethylamine; acetyl chloride; sodium iodide; sodium hydroxide; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; hexane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;