(Z)-N¹-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-N³-(4-methoxyphenyl)malonamide

Base Information

• Chemical Name: (Z)-N¹-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-N³-(4-methoxyphenyl)malonamide
• CAS No.: 1474049-69-8
• Molecular Formula: C₂₃H₂₀N₄O₄
• Molecular Weight: 416.436

Synonyms:(Z)-N¹-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-N³-(4-methoxyphenyl)malonamide

Chemical Property of (Z)-N¹-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-N³-(4-methoxyphenyl)malonamide

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Technology Process of (Z)-N¹-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-N³-(4-methoxyphenyl)malonamide

There total 4 articles about (Z)-N¹-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-N³-(4-methoxyphenyl)malonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

→ (Z)-N1-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-N3-(4-methoxyphenyl)malonamide (1474049-69-8)

Guidance literature:

With pyrrolidine; In ethanol; at 100 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

2-pyrrole aldehyde (1003-29-8,254729-95-8) + N1-(4-methoxyphenyl)-N3-(2-oxoindolin-6-yl)malonamide (1621689-23-3) → (Z)-N1-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-N3-(4-methoxyphenyl)malonamide (1474049-69-8)

Guidance literature:

With pyrrolidine; In ethanol; at 100 ℃; Microwave irradiation;

DOI:10.1016/j.ejmech.2014.07.033

Reference yield:

3-((4-methoxyphenyl)amino)-3-oxopropanoic acid (61916-60-7) → (Z)-N1-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-N3-(4-methoxyphenyl)malonamide (1474049-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide; acetonitrile / 3 h / 20 °C

2: pyrrolidine / ethanol / 100 °C / Microwave irradiation

With pyrrolidine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In ethanol; N,N-dimethyl-formamide; acetonitrile; 2: |Aldol Condensation;

DOI:10.1016/j.ejmech.2014.07.033

upstream raw materials:

3-((4-methoxyphenyl)amino)-3-oxopropanoic acid

2-pyrrole aldehyde

N¹-(4-methoxyphenyl)-N³-(2-oxoindolin-6-yl)malonamide

ethyl 3-((4-methoxyphenyl)amino)-3-oxopropanoate

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