5'-O-(4,4'-dimethoxytrityl)-2'-C-[4-{2-(pyrene-1-yl)ethyl}-1H-1,2,3-triazol-1-yl]-2'-deoxyuridine

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Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2'-C-[4-{2-(pyrene-1-yl)ethyl}-1H-1,2,3-triazol-1-yl]-2'-deoxyuridine
CAS No.:1350452-70-8
Molecular Formula:C₅₀H₄₃N₅O₇
Molecular Weight:825.921
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-C-[4-{2-(pyrene-1-yl)ethyl}-1H-1,2,3-triazol-1-yl]-2'-deoxyuridine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-C-[4-{2-(pyrene-1-yl)ethyl}-1H-1,2,3-triazol-1-yl]-2'-deoxyuridine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-C-[4-{2-(pyrene-1-yl)ethyl}-1H-1,2,3-triazol-1-yl]-2'-deoxyuridine

There total 3 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-C-[4-{2-(pyrene-1-yl)ethyl}-1H-1,2,3-triazol-1-yl]-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1350452-66-2
4-(pyren-1-yl)-but-1-yne

: 177980-10-8
2'-azido-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine

: 1350452-70-8
5'-O-(4,4'-dimethoxytrityl)-2'-C-[4-{2-(pyrene-1-yl)ethyl}-1H-1,2,3-triazol-1-yl]-2'-deoxyuridine

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; water; tert-butyl alcohol; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jo201845z

Reference yield:

: 1350452-65-1
1-(pyren-1-yl)-but-3-yn-1-ol

: 1350452-70-8
5'-O-(4,4'-dimethoxytrityl)-2'-C-[4-{2-(pyrene-1-yl)ethyl}-1H-1,2,3-triazol-1-yl]-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 1 h / 20 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C / Inert atmosphere

With triethylsilane; copper(ll) sulfate pentahydrate; boron trifluoride diethyl etherate; sodium L-ascorbate; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo201845z

Reference yield:

: 3029-19-4
pyrene-1-aldehyde

: 1350452-70-8
5'-O-(4,4'-dimethoxytrityl)-2'-C-[4-{2-(pyrene-1-yl)ethyl}-1H-1,2,3-triazol-1-yl]-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 3 steps

1: zinc / tetrahydrofuran / 4 h / 45 °C / Inert atmosphere

2: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 1 h / 20 °C

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C / Inert atmosphere

With triethylsilane; copper(ll) sulfate pentahydrate; boron trifluoride diethyl etherate; sodium L-ascorbate; zinc; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo201845z