2,5-dimethyl-3,4,6-trimethoxybenzyl chloride

Base Information

• Chemical Name: 2,5-dimethyl-3,4,6-trimethoxybenzyl chloride
• CAS No.: 107301-83-7
• Molecular Formula: C₁₂H₁₇ClO₃
• Molecular Weight: 244.718
• Mol file: 107301-83-7.mol

Synonyms:2,5-dimethyl-3,4,6-trimethoxybenzyl chloride

Chemical Property of 2,5-dimethyl-3,4,6-trimethoxybenzyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-dimethyl-3,4,6-trimethoxybenzyl chloride

There total 3 articles about 2,5-dimethyl-3,4,6-trimethoxybenzyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3,6-dimethyl-1,2,4-trimethoxybenzene (92421-46-0) + chloromethyl methyl ether (107-30-2) → 2,5-dimethyl-3,4,6-trimethoxybenzyl chloride (107301-83-7)

Guidance literature:

With tin(IV) chloride; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1021/ja00243a032

Reference yield:

2,5-Dimethyl-1,4-benzoquinone (137-18-8) → 2,5-dimethyl-3,4,6-trimethoxybenzyl chloride (107301-83-7)

Guidance literature:

Multi-step reaction with 3 steps

2: 75 percent / NaOH / methanol; H₂O

3: 92 percent / SnCl₄ / CH₂Cl₂ / 3 h / Ambient temperature

With sodium hydroxide; tin(IV) chloride; In methanol; dichloromethane; water;

DOI:10.1021/ja00243a032

Reference yield:

2,5-dimethyl-3,4-di-acetoxyphenyl acetate (40853-36-9) → 2,5-dimethyl-3,4,6-trimethoxybenzyl chloride (107301-83-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / NaOH / methanol; H₂O

2: 92 percent / SnCl₄ / CH₂Cl₂ / 3 h / Ambient temperature

With sodium hydroxide; tin(IV) chloride; In methanol; dichloromethane; water;

DOI:10.1021/ja00243a032

upstream raw materials:

3,6-dimethyl-1,2,4-trimethoxybenzene

chloromethyl methyl ether

2,5-Dimethyl-1,4-benzoquinone

2,5-dimethyl-3,4-di-acetoxyphenyl acetate

Downstream raw materials:

2,4,5-trimethoxy-3,6-((dimethylbenzyl)trimethyl)silane