N-(5-chloropyridine-2-yl)-2-[2-fluoro-4-methylaminophenylcarbonylamino]-5-methylbenzamide

Base Information

Chemical Name:N-(5-chloropyridine-2-yl)-2-[2-fluoro-4-methylaminophenylcarbonylamino]-5-methylbenzamide
CAS No.:1333127-30-2
Molecular Formula:C₂₁H₁₈ClFN₄O₂
Molecular Weight:412.851
Hs Code.:

Synonyms:N-(5-chloropyridine-2-yl)-2-[2-fluoro-4-methylaminophenylcarbonylamino]-5-methylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-chloropyridine-2-yl)-2-[2-fluoro-4-methylaminophenylcarbonylamino]-5-methylbenzamide

Chemical Property:

Purity/Quality:

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Technology Process of N-(5-chloropyridine-2-yl)-2-[2-fluoro-4-methylaminophenylcarbonylamino]-5-methylbenzamide

There total 3 articles about N-(5-chloropyridine-2-yl)-2-[2-fluoro-4-methylaminophenylcarbonylamino]-5-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333127-29-9
N-(5-chloropyridine-2-yl)-2-[2-fluoro-4-trifluoroacetyl(methyl)aminophenylcarbonylamino]-5-methylbenzamide

: 1333127-30-2
N-(5-chloropyridine-2-yl)-2-[2-fluoro-4-methylaminophenylcarbonylamino]-5-methylbenzamide

Guidance literature:: With water; sodium hydroxide; In ethanol; for 1h;

Reference yield:

: 1333127-28-8
2-fluoro-4-[trifluoroacetyl(methyl)amino]benzoic acid

: 1333127-30-2
N-(5-chloropyridine-2-yl)-2-[2-fluoro-4-methylaminophenylcarbonylamino]-5-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 48 h

2: sodium hydroxide; water / ethanol / 1 h

With water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethanol;

Reference yield:

: 173951-99-0
2-fluoro-4-(methylamino)benzoic acid

: 1333127-30-2
N-(5-chloropyridine-2-yl)-2-[2-fluoro-4-methylaminophenylcarbonylamino]-5-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1 h

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 48 h

3: sodium hydroxide; water / ethanol / 1 h

With water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethanol;