(S)-1-((R)-2-Amino-propionyl)-pyrrolidine-2-carboxylic acid benzyl ester

Base Information

Chemical Name:(S)-1-((R)-2-Amino-propionyl)-pyrrolidine-2-carboxylic acid benzyl ester
CAS No.:120979-63-7
Molecular Formula:C₁₅H₂₀N₂O₃
Molecular Weight:276.335
Hs Code.:

Synonyms:(S)-1-((R)-2-Amino-propionyl)-pyrrolidine-2-carboxylic acid benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-((R)-2-Amino-propionyl)-pyrrolidine-2-carboxylic acid benzyl ester

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Technology Process of (S)-1-((R)-2-Amino-propionyl)-pyrrolidine-2-carboxylic acid benzyl ester

There total 4 articles about (S)-1-((R)-2-Amino-propionyl)-pyrrolidine-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41036-21-9
(S)-benzyl 1-((R)-2-(tert-butoxycarbonylamino)propanoyl)pyrrolidine-2-carboxylate

: 120979-63-7
(S)-1-((R)-2-Amino-propionyl)-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: With hydrogenchloride; methoxybenzene; In 1,4-dioxane; for 0.5h; Ambient temperature;
DOI:10.1246/bcsj.60.2101

Reference yield:

: 118554-12-4
Benzyl N-tert-butyloxycarbonyl-(R,S)-alanyl-(S)-prolinate

: 62361-31-3,120979-63-7
(R,S)-Ala-(S)-Pro-OBzl

Guidance literature:: With trifluoroacetic acid; In chloroform; at 0 ℃; for 1h;
DOI:10.1055/s-1988-27625

Reference yield:

: 16652-71-4
benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride

: 120979-63-7
(S)-1-((R)-2-Amino-propionyl)-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide, 1-hydroxybenzotriazole, NMM / CHCl₃ / 1.) 0 deg C, 2 h, 2.) room temp.

2: 4M HCl, anisole / dioxane / 0.5 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; methoxybenzene; dicyclohexyl-carbodiimide; In 1,4-dioxane; chloroform;
DOI:10.1246/bcsj.60.2101