4-Methyl-benzenesulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester

Base Information

Chemical Name:4-Methyl-benzenesulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester
CAS No.:446021-68-7
Molecular Formula:C₂₅H₂₇NO₄S₂
Molecular Weight:469.626
Hs Code.:

Synonyms:4-Methyl-benzenesulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester

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Chemical Property of 4-Methyl-benzenesulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester

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Technology Process of 4-Methyl-benzenesulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester

There total 4 articles about 4-Methyl-benzenesulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 4294-57-9
para-methylphenylmagnesium bromide

: 446021-62-1
(2S,3aR,8aS)-3-(mesitylsulfonyl)-3,3a,8,8a-tetrahydroindeno[1,2-d][1,2,3]oxathiazole-2-oxide

: 446021-68-7
4-Methyl-benzenesulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester

Guidance literature:: In tetrahydrofuran; at -78 ℃;
DOI:10.1016/j.tet.2005.03.122

Reference yield:

: 861821-86-5
2-Methyl-propane-2-sulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester

: 446021-68-7
4-Methyl-benzenesulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h / -45 °C

1.2: tetrahydrofuran; hexane / -78 - -75 °C

2.1: 80 percent / thionyl chloride; 3,5-lutidine / tetrahydrofuran / -45 °C

3.1: 90 percent / tetrahydrofuran / -78 °C

With 3,5-Lutidine; thionyl chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2005.03.122

Reference yield:

: 446021-63-2
(2S,3aR,8aS)-3-(2,4,6-Trimethyl-benzenesulfonyl)-3,3a,8,8a-tetrahydro-1-oxa-2-thia-3-aza-cyclopenta[a]indene 2-oxide

: 446021-68-7
4-Methyl-benzenesulfinic acid (1R,2S)-1-(2,4,6-trimethyl-benzenesulfonylamino)-indan-2-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / tetrahydrofuran / -20 - 20 °C

2.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.5 h / -45 °C

2.2: tetrahydrofuran; hexane / -78 - -75 °C

3.1: 80 percent / thionyl chloride; 3,5-lutidine / tetrahydrofuran / -45 °C

4.1: 90 percent / tetrahydrofuran / -78 °C

With 3,5-Lutidine; thionyl chloride; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2005.03.122