methyl [3-[7-chloro-3-[2-[[4-fluoro-2-(trifluoromethyl)phenyl]amino]-2-oxoethyl]-6-methyl-2-oxo-2H-chromen-4-yl]phenyl]acetate

Base Information

• Chemical Name: methyl [3-[7-chloro-3-[2-[[4-fluoro-2-(trifluoromethyl)phenyl]amino]-2-oxoethyl]-6-methyl-2-oxo-2H-chromen-4-yl]phenyl]acetate
• CAS No.: 566944-74-9
• Molecular Formula: C₂₈H₂₀ClF₄NO₅
• Molecular Weight: 561.917

Synonyms:methyl [3-[7-chloro-3-[2-[[4-fluoro-2-(trifluoromethyl)phenyl]amino]-2-oxoethyl]-6-methyl-2-oxo-2H-chromen-4-yl]phenyl]acetate

Chemical Property of methyl [3-[7-chloro-3-[2-[[4-fluoro-2-(trifluoromethyl)phenyl]amino]-2-oxoethyl]-6-methyl-2-oxo-2H-chromen-4-yl]phenyl]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl [3-[7-chloro-3-[2-[[4-fluoro-2-(trifluoromethyl)phenyl]amino]-2-oxoethyl]-6-methyl-2-oxo-2H-chromen-4-yl]phenyl]acetate

There total 13 articles about methyl [3-[7-chloro-3-[2-[[4-fluoro-2-(trifluoromethyl)phenyl]amino]-2-oxoethyl]-6-methyl-2-oxo-2H-chromen-4-yl]phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 3-[7-chloro-3-[2-[[4-fluoro-2-(trifluoromethyl)phenyl]amino]-2-oxoethyl]-6-methyl-2-oxo-2H-chromen-4-yl]benzoic acid (566944-27-2) → methyl [3-[7-chloro-3-[2-[[4-fluoro-2-(trifluoromethyl)phenyl]amino]-2-oxoethyl]-6-methyl-2-oxo-2H-chromen-4-yl]phenyl]acetate (566944-74-9)

Guidance literature:

3-[7-chloro-3-[2-[[4-fluoro-2-(trifluoromethyl)phenyl]amino]-2-oxoethyl]-6-methyl-2-oxo-2H-chromen-4-yl]benzoic acid; With oxalyl dichloride; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.5h;

diazomethane; In tetrahydrofuran; diethyl ether; at 20 ℃; for 2h;

silver(l) oxide; In methanol; for 2h; Heating / reflux;

Reference yield:

(4-chloro-2-hydroxy-5-methylphenyl)[3-(1,3-dioxolan-2-yl)phenyl]methanone (1360540-41-5) → methyl [3-[7-chloro-3-[2-[[4-fluoro-2-(trifluoromethyl)phenyl]amino]-2-oxoethyl]-6-methyl-2-oxo-2H-chromen-4-yl]phenyl]acetate (566944-74-9)

Guidance literature:

Multi-step reaction with 8 steps

1.1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 2 h / Reflux

3.1: hydrogenchloride; water; acetic acid / 1 h / Reflux

4.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 20 °C

5.1: tetrahydrofuran / 20 °C

6.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C

7.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 20 °C

8.1: N'-methyl-N'-nitro-N-nitrosoguanidine / diethyl ether / 2 h / 20 °C

8.2: 2 h / Reflux

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; water; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; N'-methyl-N'-nitro-N-nitrosoguanidine; In tetrahydrofuran; diethyl ether; water; toluene; tert-butyl alcohol;

DOI:10.1248/cpb.59.1369

Reference yield:

1-bromo-4-chloro-2-methoxy-5-methylbenzene (83803-57-0) → methyl [3-[7-chloro-3-[2-[[4-fluoro-2-(trifluoromethyl)phenyl]amino]-2-oxoethyl]-6-methyl-2-oxo-2H-chromen-4-yl]phenyl]acetate (566944-74-9)

Guidance literature:

Multi-step reaction with 10 steps

1.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 1 h / -78 °C

2.3: 4 h / Reflux

3.1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 2 h / Reflux

5.1: hydrogenchloride; water; acetic acid / 1 h / Reflux

6.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 20 °C

7.1: tetrahydrofuran / 20 °C

8.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C

9.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 20 °C

10.1: N'-methyl-N'-nitro-N-nitrosoguanidine / diethyl ether / 2 h / 20 °C

10.2: 2 h / Reflux

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; oxalyl dichloride; water; boron tribromide; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; N'-methyl-N'-nitro-N-nitrosoguanidine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; toluene; tert-butyl alcohol;

DOI:10.1248/cpb.59.1369

upstream raw materials:

diazomethane

3-[7-chloro-3-[2-[[4-fluoro-2-(trifluoromethyl)phenyl]amino]-2-oxoethyl]-6-methyl-2-oxo-2H-chromen-4-yl]benzoic acid

2-bromo-5-chloro-4-methylphenol

1-bromo-4-chloro-2-methoxy-5-methylbenzene

Downstream raw materials:

[3-[7-chloro-3-[2-[[4-fluoro-2-(trifluoromethyl)phenyl]amino]-2-oxoethyl]-6-methyl-2-oxo-2H-chromen-4-yl]phenyl]acetic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 566944-74-9 methyl [3-[7-chloro-3-[2-[[4-fluoro-2-(trifluoromethyl)phenyl]amino]-2-oxoethyl]-6-methyl-2-oxo-2H-chromen-4-yl]phenyl]acetate

Send

Send

Metric Ton KG G Pound L ML

Send

Send