N²,O⁶-di(tert-butyl)(isobutyl)silyl-5'-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

Base Information

Chemical Name:N²,O⁶-di(tert-butyl)(isobutyl)silyl-5'-(4,4'-dimethoxytrityl)-2'-deoxyguanosine
CAS No.:1430099-62-9
Molecular Formula:C₅₅H₈₃N₅O₆Si₂
Molecular Weight:966.465
Hs Code.:

N<SUP>2</SUP>,O<SUP>6</SUP>-di(tert-butyl)(isobutyl)silyl-5'-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

Synonyms:N²,O⁶-di(tert-butyl)(isobutyl)silyl-5'-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N²,O⁶-di(tert-butyl)(isobutyl)silyl-5'-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

Chemical Property:

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Technology Process of N²,O⁶-di(tert-butyl)(isobutyl)silyl-5'-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

There total 4 articles about N²,O⁶-di(tert-butyl)(isobutyl)silyl-5'-(4,4'-dimethoxytrityl)-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: C₃₄H₆₅N₅O₄Si₂

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1430099-62-9
N²,O⁶-di(tert-butyl)(isobutyl)silyl-5'-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

Guidance literature:: With pyridine; N-ethyl-N,N-diisopropylamine; at 20 ℃;

Reference yield:

: 1314639-86-5
di-tert-butylisobutylsilyl trifluoromethanesulfonate

: 1430099-62-9
N²,O⁶-di(tert-butyl)(isobutyl)silyl-5'-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; triethylamine / 1,4-dioxane / 72 h / 60 °C / Inert atmosphere

2: ammonia; methanol

3: N-ethyl-N,N-diisopropylamine; pyridine / 20 °C

With pyridine; methanol; dmap; ammonia; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane;
DOI:10.1021/ja400898s

Reference yield:

: 69992-10-5
3',5'-di-O-acetyl-2'-deoxyguanosine

: 1430099-62-9
N²,O⁶-di(tert-butyl)(isobutyl)silyl-5'-(4,4'-dimethoxytrityl)-2'-deoxyguanosine

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; triethylamine / 1,4-dioxane / 72 h / 60 °C / Inert atmosphere

2: ammonia; methanol

3: N-ethyl-N,N-diisopropylamine; pyridine / 20 °C

With pyridine; methanol; dmap; ammonia; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane;
DOI:10.1021/ja400898s