6,7-Dimethoxyquinoxalin-5-amine

Base Information

• Chemical Name: 6,7-Dimethoxyquinoxalin-5-amine
• CAS No.: 6295-30-3
• Molecular Formula: C₁₀H₁₁N₃O₂
• Molecular Weight: 205.216
• NSC Number: 11832
• DSSTox Substance ID: DTXSID80279232
• Wikidata: Q82011673
• Mol file: 6295-30-3.mol

Synonyms:6,7-dimethoxyquinoxalin-5-amine;6295-30-3;NSC11832;DTXSID80279232;NSC 11832;NSC-11832

Chemical Property of 6,7-Dimethoxyquinoxalin-5-amine

Chemical Property:

• Vapor Pressure: 1.08E-05mmHg at 25°C
• Boiling Point: 370.8°C at 760 mmHg
• PKA: 2.48±0.30(Predicted)
• Flash Point: 178.1°C
• Density: 1.28g/cm³
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 205.085126602
• Heavy Atom Count: 15
• Complexity: 215

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=NC=CN=C2C(=C1OC)N

Technology Process of 6,7-Dimethoxyquinoxalin-5-amine

There total 4 articles about 6,7-Dimethoxyquinoxalin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6,7-Dimethoxyquinoxaline (6295-29-0) → 6,7-dimethoxy-quinoxalin-5-ylamine (6295-30-3)

Guidance literature:

Multi-step reaction with 2 steps

1: concentrated H₂SO₄; aqueous HNO₃

2: iron; aqueous acetic acid

With sulfuric acid; nitric acid; iron; acetic acid;

DOI:10.1021/jo01168a006

Reference yield:

6,7-dimethoxy-5-nitro-quinoxaline (858477-75-5) → 6,7-dimethoxy-quinoxalin-5-ylamine (6295-30-3)

Guidance literature:

With iron; acetic acid;

DOI:10.1021/jo01168a006

Reference yield:

1,2-dimethoxy-3,4,5-trinitrobenzene (17418-07-4) → 6,7-dimethoxy-quinoxalin-5-ylamine (6295-30-3)

Guidance literature:

Multi-step reaction with 2 steps

1: iron; aqueous hydrochloric acid; ethanol / unter Zusatz von Zinn(II)-chlorid

With hydrogenchloride; ethanol; iron;

DOI:10.1021/jo01168a006

upstream raw materials:

6,7-dimethoxy-5-nitro-quinoxaline

4,5-dimethoxy-benzene-1,2,3-triyltriamine

glyoxal sodium bisulfite

6,7-Dimethoxyquinoxaline

Downstream raw materials:

N-acetyl-sulfanilic acid-(6,7-dimethoxy-quinoxalin-5-ylamide)