benazepril hydrochloride

Base Information

• Chemical Name: benazepril hydrochloride
• CAS No.: 215447-89-5
• Molecular Formula: C₂₄H₂₈N₂O₅*ClH
• Molecular Weight: 460.958
• Hs Code.: 2933790002
• Mol file: 215447-89-5.mol

Synonyms:1H-1-Benzazepine-1-aceticacid,3-[[(1R)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-,monohydrochloride, (3R)- (9CI);

Chemical Property of benazepril hydrochloride

Chemical Property:

• PSA: 95.94000
• LogP: 3.83100

Purity/Quality:

99% ^*data from raw suppliers

(3R)-BenazeprilHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (R)-Benazepril Hydrochloride is a stereoisomer of Benazepril (B119750), used as an antihypertensive; angiotensin converting enzyme inhibitor.

Technology Process of benazepril hydrochloride

There total 49 articles about benazepril hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.6%

(2S,3'S)-2-(1-tert-butoxycarbonylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-4-phenylbutyric acid ethyl ester (109010-61-9) → benazepril hydrochloride (86541-74-4,215447-89-5,88372-38-7)

Guidance literature:

With hydrogenchloride; In ethyl acetate;

Reference yield: 91.0%

ethyl (S)-2-(((S)-1-(2-(benzyloxy)-2-oxoethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3- yl)amino)-4-phenylbutanoate → benazepril hydrochloride (86541-74-4,215447-89-5,88372-38-7)

Guidance literature:

ethyl (S)-2-(((S)-1-(2-(benzyloxy)-2-oxoethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3- yl)amino)-4-phenylbutanoate; With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 3h;

With hydrogenchloride; In ethyl acetate; acetone; Reflux;

DOI:10.1007/s12039-021-01892-8

Reference yield: 25.0%

2-oxo-4-phenylbutanoic acid ethyl ester (64920-29-2) + (3S)-3-amino-1-(carboxymethyl)-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one sodium salt (86499-53-8) → benazepril hydrochloride (86541-74-4,215447-89-5,88372-38-7) + (3S)-1-(carboxymethyl)-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one hydrochloride (86541-77-7,215447-89-5,88372-38-7)

Guidance literature:

With sodium cyanoborohydride; In methanol; acetic acid; Ambient temperature;

DOI:10.1021/jm00148a023

upstream raw materials:

2-oxo-4-phenylbutanoic acid ethyl ester

(3S)-3-amino-1-(carboxymethyl)-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one sodium salt

(2S,3'S)-2-(1-tert-butoxycarbonylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-4-phenylbutyric acid ethyl ester

2-acetylnitrobenzene