4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinoline

Base Information

Chemical Name:4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinoline
CAS No.:1436418-01-7
Molecular Formula:C₂₅H₂₈FN₃O₅
Molecular Weight:469.513
Hs Code.:

Synonyms:4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinoline

Suppliers and Price of 4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinoline

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Technology Process of 4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinoline

There total 14 articles about 4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.7%

: 403-19-0
2-fluoro-4-nitrophenol

: 1436417-99-0
4-chloro-6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)-quinoline

: 1436418-01-7
4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinoline

Guidance literature:: In chlorobenzene; at 140 ℃; for 30h;
DOI:10.1016/j.bmc.2013.04.013

Reference yield: 75.0%

: 479690-08-9
1-(2-fluoro-4-nitrophenyl)-6-hydroxy-7-methoxy-quinoline

: 1-(3-chloropropyl)-4-methylpiperidine hydrochloride

: 1436418-01-7
4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinoline

Guidance literature:: With caesium carbonate; potassium iodide; In acetonitrile; at 20 ℃; for 3.75h; Reflux;
DOI:10.1021/acs.jmedchem.8b00672

Reference yield:

: 1160707-44-7
1-[4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl]ethan-1-one

: 1436418-01-7
4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinoline

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 10 h / 110 °C

2: acetic acid / 2 h / 60 - 80 °C

3: acetonitrile / 10 h / 85 °C

4: trichlorophosphate / acetonitrile / 6 h / 85 °C

5: chlorobenzene / 30 h / 140 °C

With trichlorophosphate; In acetic acid; chlorobenzene; toluene; acetonitrile;
DOI:10.1016/j.bmc.2013.04.013