7-CHLORO-1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YLAMINE HYDROCHLORIDE

Base Information

• Chemical Name: 7-CHLORO-1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YLAMINE HYDROCHLORIDE
• CAS No.: 215315-62-1
• Molecular Formula: C₁₀H₁₂FN
• Molecular Weight: 165.21
• Mol file: 215315-62-1.mol

Synonyms:7-Fluoro-1,2,3,4-tetrahydronaphthalen-1-ylamine

Chemical Property of 7-CHLORO-1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YLAMINE HYDROCHLORIDE

Chemical Property:

• PSA: 26.02000
• LogP: 3.66410

Purity/Quality:

97% ^*data from raw suppliers

7-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-CHLORO-1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YLAMINE HYDROCHLORIDE

There total 2 articles about 7-CHLORO-1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YLAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

→ 7-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine (215315-62-1,462105-66-4)

Guidance literature:

With ammonium acetate; sodium cyanoborohydride; In ethanol; at 130 ℃; Sealed tube; Microwave irradiation;

Reference yield:

C11H12FNO (1384839-45-5) → 7-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine (215315-62-1,462105-66-4)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 60 ℃;

DOI:10.1021/jm800809f

Reference yield:

7-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine (215315-62-1,462105-66-4) → (R)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine (1055949-62-6,462105-66-4) + C10H10FN

Guidance literature:

With borane-ammonia complex; monoamine oxidase variant D₉ from Aspergillus niger; In dimethyl sulfoxide; at 37 ℃; for 24h; pH=9; enantioselective reaction; Resolution of racemate; Enzymatic reaction;

DOI:10.1016/j.bmc.2017.07.023

upstream raw materials:

C₁₁H₁₂FNO

Downstream raw materials:

(R)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine

Refernces

• 1、 S?rensen, Ulrik S.,Str?b?k, Dorte,Christophersen, Palle,Hougaard, Charlotte,Jensen, Marianne L.,Nielsen, Elsebet ?.,Peters, Dan,Teuber, Lene. "Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators of small conductance Ca2+-activated K+ channels". supporting information; scheme or table. p. 7625 - 7634. Retrieved 2009/12/07.