diisopropyl-[1-oxo-5-(toluene-4-sulfonyl)-2,4,5,6,7,7a-hexahydro-1H-5-aza-1λ⁵-phospha-inden-1-yl]-amine

Base Information

• Chemical Name: diisopropyl-[1-oxo-5-(toluene-4-sulfonyl)-2,4,5,6,7,7a-hexahydro-1H-5-aza-1λ⁵-phospha-inden-1-yl]-amine
• CAS No.: 875138-39-9
• Molecular Formula: C₂₀H₃₁N₂O₃PS
• Molecular Weight: 410.518

Synonyms:diisopropyl-[1-oxo-5-(toluene-4-sulfonyl)-2,4,5,6,7,7a-hexahydro-1H-5-aza-1λ⁵-phospha-inden-1-yl]-amine

Chemical Property of diisopropyl-[1-oxo-5-(toluene-4-sulfonyl)-2,4,5,6,7,7a-hexahydro-1H-5-aza-1λ⁵-phospha-inden-1-yl]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diisopropyl-[1-oxo-5-(toluene-4-sulfonyl)-2,4,5,6,7,7a-hexahydro-1H-5-aza-1λ⁵-phospha-inden-1-yl]-amine

There total 3 articles about diisopropyl-[1-oxo-5-(toluene-4-sulfonyl)-2,4,5,6,7,7a-hexahydro-1H-5-aza-1λ⁵-phospha-inden-1-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

N,N-diisopropylphosphoramide dichloride (921-26-6) + N-p-toluenesulfonyl-3-vinyl-1,2,5,6-tetrahydropyridine (680577-25-7) → diisopropyl-[1-oxo-5-(toluene-4-sulfonyl)-2,4,5,6,7,7a-hexahydro-1H-5-aza-1λ5-phospha-inden-1-yl]-amine (875138-39-9)

Guidance literature:

N,N-diisopropylphosphoramide dichloride; With aluminium trichloride; In dichloromethane; at -20 - 20 ℃; for 1h;

N-p-toluenesulfonyl-3-vinyl-1,2,5,6-tetrahydropyridine; In dichloromethane; at 20 ℃; for 16h;

With ethylenediaminetetraacetic acid; sodium hydrogencarbonate; at 20 ℃; for 5h;

DOI:10.1055/s-2005-921902

Reference yield:

N-propargyl-N-butene trifluoroacetamide (875138-34-4) → diisopropyl-[1-oxo-5-(toluene-4-sulfonyl)-2,4,5,6,7,7a-hexahydro-1H-5-aza-1λ5-phospha-inden-1-yl]-amine (875138-39-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 100 percent / Grubb's catalyst / CH₂Cl₂ / 22 h / 20 °C

2.1: 51 percent / aq. K₂CO₃ / methanol / 4 h / 20 - 50 °C

3.1: AlCl₃ / CH₂Cl₂ / 1 h / -20 - 20 °C

3.2: CH₂Cl₂ / 16 h / 20 °C

3.3: 63 percent / EDTA; aq. NaHCO₃ / 5 h / 20 °C

With aluminium trichloride; potassium carbonate; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In methanol; dichloromethane;

DOI:10.1055/s-2005-921902

Reference yield:

2,2,2-trifluoro-1-(5-vinyl-3,6-dihydro-2H-pyridin-1-yl)-ethanone (875138-36-6) → diisopropyl-[1-oxo-5-(toluene-4-sulfonyl)-2,4,5,6,7,7a-hexahydro-1H-5-aza-1λ5-phospha-inden-1-yl]-amine (875138-39-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 51 percent / aq. K₂CO₃ / methanol / 4 h / 20 - 50 °C

2.1: AlCl₃ / CH₂Cl₂ / 1 h / -20 - 20 °C

2.2: CH₂Cl₂ / 16 h / 20 °C

2.3: 63 percent / EDTA; aq. NaHCO₃ / 5 h / 20 °C

With aluminium trichloride; potassium carbonate; In methanol; dichloromethane;

DOI:10.1055/s-2005-921902

upstream raw materials:

N,N-diisopropylphosphoramide dichloride

N-p-toluenesulfonyl-3-vinyl-1,2,5,6-tetrahydropyridine

2,2,2-trifluoro-1-(5-vinyl-3,6-dihydro-2H-pyridin-1-yl)-ethanone

N-propargyl-N-butene trifluoroacetamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 875138-39-9 diisopropyl-[1-oxo-5-(toluene-4-sulfonyl)-2,4,5,6,7,7a-hexahydro-1H-5-aza-1λ⁵-phospha-inden-1-yl]-amine

Send

Send

Metric Ton KG G Pound L ML

Send

Send