H-L-Phe-Aib₄-GlyNH₂

Base Information

• Chemical Name: H-L-Phe-Aib₄-GlyNH₂
• CAS No.: 1372814-16-8
• Molecular Formula: C₂₇H₄₃N₇O₆
• Molecular Weight: 561.682
• Mol file: 1372814-16-8.mol

Synonyms:H-L-Phe-Aib₄-GlyNH₂

Chemical Property of H-L-Phe-Aib₄-GlyNH₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H-L-Phe-Aib₄-GlyNH₂

There total 5 articles about H-L-Phe-Aib₄-GlyNH₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cbz-Phe-Aib4-GlyNH2 (1372814-21-5) → H-L-Phe-Aib4-GlyNH2 (1372814-16-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; acetic acid; In ethanol; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201107583

Reference yield:

N3Aib4-OH (1187839-35-5) → H-L-Phe-Aib4-GlyNH2 (1372814-16-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 3 h / 120 °C / Inert atmosphere

2: triethylamine / acetonitrile / 72 h / Reflux; Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / Inert atmosphere

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

5: palladium 10% on activated carbon; hydrogen; acetic acid / ethanol / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; acetonitrile;

DOI:10.1002/anie.201107583

Reference yield:

C16H26N6O4 (1187839-36-6) → H-L-Phe-Aib4-GlyNH2 (1372814-16-8)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / acetonitrile / 72 h / Reflux; Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / Inert atmosphere

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen; acetic acid / ethanol / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; acetonitrile;

DOI:10.1002/anie.201107583

upstream raw materials:

N₃Aib₄-OH

C₁₆H₂₆N₆O₄

N₃-(Aib)4-GlyNH₂

GlyNH₂-Aib₄-NH₂

Downstream raw materials:

C₂₉H₄₅N₇O₇

C₃₄H₄₆BrN₇O₇

m-NO₂Bz-L-Phe-Aib₄-GlyNH₂