2-[(Z)-3-{[1-(tert-butyl)-1,1-dimethyl-silanyl]oxy}-1-propenyl]-3,6-dimethylphenyl acetate

Base Information

• Chemical Name: 2-[(Z)-3-{[1-(tert-butyl)-1,1-dimethyl-silanyl]oxy}-1-propenyl]-3,6-dimethylphenyl acetate
• CAS No.: 300766-92-1
• Molecular Formula: C₁₉H₃₀O₃Si
• Molecular Weight: 334.531
• Mol file: 300766-92-1.mol

Synonyms:2-[(Z)-3-{[1-(tert-butyl)-1,1-dimethyl-silanyl]oxy}-1-propenyl]-3,6-dimethylphenyl acetate

Chemical Property of 2-[(Z)-3-{[1-(tert-butyl)-1,1-dimethyl-silanyl]oxy}-1-propenyl]-3,6-dimethylphenyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(Z)-3-{[1-(tert-butyl)-1,1-dimethyl-silanyl]oxy}-1-propenyl]-3,6-dimethylphenyl acetate

There total 5 articles about 2-[(Z)-3-{[1-(tert-butyl)-1,1-dimethyl-silanyl]oxy}-1-propenyl]-3,6-dimethylphenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

acetic anhydride (108-24-7) + 2-[(Z)-3-{[1-(tert-butyl)-1,1-dimethyl-silanyl]oxy}-1-propenyl]-3,6-dimethylphenol (300766-91-0) → 2-[(Z)-3-{[1-(tert-butyl)-1,1-dimethyl-silanyl]oxy}-1-propenyl]-3,6-dimethylphenyl acetate (300766-92-1)

Guidance literature:

With dmap; triethylamine;

DOI:10.1016/S0960-894X(99)00289-9

Reference yield:

5,8-dimethyl-2H-1-benzopyran-2-one (50396-54-8) → 2-[(Z)-3-{[1-(tert-butyl)-1,1-dimethyl-silanyl]oxy}-1-propenyl]-3,6-dimethylphenyl acetate (300766-92-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 52 percent / LAH / diethyl ether / 0.25 h / 0 °C

2: 82 percent / DMAP / tetrahydrofuran / 8 h / 0 °C

3: 90 percent / DMAP; TEA / CH₂Cl₂ / 1 h / 20 °C

With dmap; lithium aluminium tetrahydride; TEA; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1248/cpb.48.1138

Reference yield:

2-[(Z)-3-hydroxy-1-propenyl]-3,6-dimethylphenol (300766-90-9) → 2-[(Z)-3-{[1-(tert-butyl)-1,1-dimethyl-silanyl]oxy}-1-propenyl]-3,6-dimethylphenyl acetate (300766-92-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / DMAP / tetrahydrofuran / 8 h / 0 °C

2: 90 percent / DMAP; TEA / CH₂Cl₂ / 1 h / 20 °C

With dmap; TEA; In tetrahydrofuran; dichloromethane;

DOI:10.1248/cpb.48.1138

upstream raw materials:

acetic anhydride

2-[(Z)-3-{[1-(tert-butyl)-1,1-dimethyl-silanyl]oxy}-1-propenyl]-3,6-dimethylphenol

2,5-Dimethylphenol

5,8-dimethyl-2H-1-benzopyran-2-one

Downstream raw materials:

2-[(Z)-3-hydroxy-1-propenyl]-3,6-dimethylphenyl acetate

3,6-dimethyl-2-[(Z)-3-oxo-1-propenyl]phenyl acetate

(Z)-3-[2-(acetyloxy)-3,6-dimethylphenyl]acrylic acid

2-[(Z)-2-(diethylcarbamoyl)vinyl]-3,6-dimethylphenyl acetate