[1-(4-Chloro-benzyl)-4-methyl-6-(quinolin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-methanol

Base Information

• Chemical Name: [1-(4-Chloro-benzyl)-4-methyl-6-(quinolin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-methanol
• CAS No.: 170243-17-1
• Molecular Formula: C₂₉H₂₅ClN₂O₂S
• Molecular Weight: 501.049

Synonyms:[1-(4-Chloro-benzyl)-4-methyl-6-(quinolin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-methanol

Chemical Property of [1-(4-Chloro-benzyl)-4-methyl-6-(quinolin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-methanol

Chemical Property:

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Technology Process of [1-(4-Chloro-benzyl)-4-methyl-6-(quinolin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-methanol

There total 1 articles about [1-(4-Chloro-benzyl)-4-methyl-6-(quinolin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H18ClNO2S → [1-(4-Chloro-benzyl)-4-methyl-6-(quinolin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-methanol (170243-17-1)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; acetonitrile; at 60 ℃; for 16h;

DOI:10.1021/jm00022a020

Reference yield:

[1-(4-Chloro-benzyl)-4-methyl-6-(quinolin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-methanol (170243-17-1) → 2-<<1-(4-chlorobenzyl)-4-methyl-6-(quinolin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>methoxy>phenylacetic acid

Guidance literature:

Multi-step reaction with 2 steps

1: Ph₃P, DEAD / tetrahydrofuran / 0.5 h

2: 1 N aq. LiOH / tetrahydrofuran; methanol / 1.5 h / 50 °C

With lithium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;

DOI:10.1021/jm00022a020

Reference yield:

methyl (2-hydroxyphenyl)acetate (22446-37-3) + [1-(4-Chloro-benzyl)-4-methyl-6-(quinolin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-methanol (170243-17-1) → {2-[1-(4-Chloro-benzyl)-4-methyl-6-(quinolin-2-ylmethoxy)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-ylmethoxy]-phenyl}-acetic acid methyl ester

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 0.5h;

DOI:10.1021/jm00022a020

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