Technology Process of N1,N3-dimethyl-5-[3-[3-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]phenyl]propyl]benzene-1,3-dicarboxamide
There total 10 articles about N1,N3-dimethyl-5-[3-[3-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]phenyl]propyl]benzene-1,3-dicarboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium on activated charcoal; hydrogen;
In
methanol;
for 5h;
under 2068.65 Torr;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 4-methylmorpholine N-oxide; methanesulfonamide; osmium(VIII) oxide; 2,6-dimethylpyridine / water; tert-butyl alcohol; tetrahydrofuran / 72 h / 20 °C
2: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C
3: tetrakis(triphenylphosphine) palladium(0) / benzene / 48 h / 100 °C
4: tetrabutylammomium bromide; palladium diacetate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 85 °C / Inert atmosphere
5: sodium methylate / methanol / 20 h / 20 °C
6: hydrogen; palladium on activated charcoal / methanol / 5 h / 2068.65 Torr
With
2,6-dimethylpyridine; dmap; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium(0); methanesulfonamide; palladium on activated charcoal; tetrabutylammomium bromide; hydrogen; sodium methylate; palladium diacetate; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol; benzene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tetrabutylammomium bromide; palladium diacetate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 85 °C / Inert atmosphere
2: sodium methylate / methanol / 20 h / 20 °C
3: hydrogen; palladium on activated charcoal / methanol / 5 h / 2068.65 Torr
With
palladium on activated charcoal; tetrabutylammomium bromide; hydrogen; sodium methylate; palladium diacetate; sodium hydrogencarbonate;
In
methanol; N,N-dimethyl-formamide;
![N<sub>1</sub>,N<sub>3</sub>-dimethyl-5-[(E)-3-[3-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]phenyl]prop-1-enyl]benzene-1,3-dicarboxamide](/Databaselist/images/loading.webp)
