(E)-2-(4,4-bis((trifluoromethyl)sulfonyl)but-1-en-1-yl)-1-bromo-4-fluorobenzene

Base Information

Chemical Name:(E)-2-(4,4-bis((trifluoromethyl)sulfonyl)but-1-en-1-yl)-1-bromo-4-fluorobenzene
CAS No.:1428869-76-4
Molecular Formula:C₁₂H₈BrF₇O₄S₂
Molecular Weight:493.218
Hs Code.:

Synonyms:(E)-2-(4,4-bis((trifluoromethyl)sulfonyl)but-1-en-1-yl)-1-bromo-4-fluorobenzene

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Chemical Property of (E)-2-(4,4-bis((trifluoromethyl)sulfonyl)but-1-en-1-yl)-1-bromo-4-fluorobenzene

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Technology Process of (E)-2-(4,4-bis((trifluoromethyl)sulfonyl)but-1-en-1-yl)-1-bromo-4-fluorobenzene

There total 4 articles about (E)-2-(4,4-bis((trifluoromethyl)sulfonyl)but-1-en-1-yl)-1-bromo-4-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1428869-53-7
(E)-2-(4,4-bis((trifluoromethyl)sulfonyl)buta-1,3-dienyl)-1-bromo-4-fluorobenzene

: 1428869-76-4
(E)-2-(4,4-bis((trifluoromethyl)sulfonyl)but-1-en-1-yl)-1-bromo-4-fluorobenzene

Guidance literature:: (E)-2-(4,4-bis((trifluoromethyl)sulfonyl)buta-1,3-dienyl)-1-bromo-4-fluorobenzene; With sodium tetrahydroborate; In ethyl acetate; at 0 ℃; for 1.5h; Inert atmosphere;

With hydrogenchloride; In hexane; dichloromethane; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.02.039

Reference yield:

: 1019852-40-4
ethyl (2E)-3-(2-bromo-5-fluorophenyl)prop-2-enoate

: 1428869-76-4
(E)-2-(4,4-bis((trifluoromethyl)sulfonyl)but-1-en-1-yl)-1-bromo-4-fluorobenzene

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / hexane; dichloromethane / 3 h / 0 °C / Inert atmosphere

2.1: manganese(IV) oxide / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.1: 1,2-dichloro-ethane / 3 h / 20 °C / Inert atmosphere

4.1: sodium tetrahydroborate / ethyl acetate / 1.5 h / 0 °C / Inert atmosphere

4.2: Inert atmosphere

With manganese(IV) oxide; sodium tetrahydroborate; diisobutylaluminium hydride; In hexane; dichloromethane; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/j.tetlet.2013.02.039

Reference yield:

: 1428869-66-2
(E)-3-(2-bromo-5-fluorophenyl)prop-2-en-1-ol

: 1428869-76-4
(E)-2-(4,4-bis((trifluoromethyl)sulfonyl)but-1-en-1-yl)-1-bromo-4-fluorobenzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: manganese(IV) oxide / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.1: 1,2-dichloro-ethane / 3 h / 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate / ethyl acetate / 1.5 h / 0 °C / Inert atmosphere

3.2: Inert atmosphere

With manganese(IV) oxide; sodium tetrahydroborate; In dichloromethane; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/j.tetlet.2013.02.039