methyl (1R,2R,6R)-2-((tert-butoxycarbonyl)amino)-6-(2-methoxycarbonylmethyl)cyclohexanecarboxylate

Base Information

Chemical Name:methyl (1R,2R,6R)-2-((tert-butoxycarbonyl)amino)-6-(2-methoxycarbonylmethyl)cyclohexanecarboxylate
CAS No.:1426682-83-8
Molecular Formula:C₁₆H₂₇NO₆
Molecular Weight:329.393
Hs Code.:

Synonyms:methyl (1R,2R,6R)-2-((tert-butoxycarbonyl)amino)-6-(2-methoxycarbonylmethyl)cyclohexanecarboxylate

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Chemical Property of methyl (1R,2R,6R)-2-((tert-butoxycarbonyl)amino)-6-(2-methoxycarbonylmethyl)cyclohexanecarboxylate

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Technology Process of methyl (1R,2R,6R)-2-((tert-butoxycarbonyl)amino)-6-(2-methoxycarbonylmethyl)cyclohexanecarboxylate

There total 2 articles about methyl (1R,2R,6R)-2-((tert-butoxycarbonyl)amino)-6-(2-methoxycarbonylmethyl)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 241485-17-6
methyl (1R,2R,6R,αR)-2-N-benzyl-N-α-methylbenzylamino-6-(methyloxycarbonylmethyl)cyclohexanecarboxylate

: 1426682-83-8
methyl (1R,2R,6R)-2-((tert-butoxycarbonyl)amino)-6-(2-methoxycarbonylmethyl)cyclohexanecarboxylate

Guidance literature:: With 20% palladium hydroxide-activated charcoal; hydrogen; In ethyl acetate; for 72h; under 3040.2 Torr;
DOI:10.1016/j.tetasy.2017.10.005

Reference yield:

: 34333-79-4
dimethyl (2E,7E)-nona-2,7-diene-1,9-dicarboxylate

: 1426682-83-8
methyl (1R,2R,6R)-2-((tert-butoxycarbonyl)amino)-6-(2-methoxycarbonylmethyl)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / -78 °C

2: 10 wt% Pd(OH)2 on carbon; hydrogen / ethyl acetate / 72 h / 2625.26 Torr

With 10 wt% Pd(OH)2 on carbon; hydrogen; In tetrahydrofuran; ethyl acetate; 1: |Michael Addition;
DOI:10.1055/s-0032-1317950

Reference yield: 77.0%

: 1426682-83-8
methyl (1R,2R,6R)-2-((tert-butoxycarbonyl)amino)-6-(2-methoxycarbonylmethyl)cyclohexanecarboxylate

: tert-butyl ((1R,2R,3R)-3-(2-hydroxyethyl)-2-(hydroxymethyl)cyclohexyl)carbamate

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tetasy.2017.10.005