N⁶-benzoyl-9-{2'-[(tert-butyl)dimethylsilyloxy]-4'-hydroxycyclohexyl}adenine

Base Information

Chemical Name:N⁶-benzoyl-9-{2'-[(tert-butyl)dimethylsilyloxy]-4'-hydroxycyclohexyl}adenine
CAS No.:878550-03-9
Molecular Formula:C₂₄H₃₃N₅O₃Si
Molecular Weight:467.643
Hs Code.:

N<sup>6</sup>-benzoyl-9-{2'-[(tert-butyl)dimethylsilyloxy]-4'-hydroxycyclohexyl}adenine

Synonyms:N⁶-benzoyl-9-{2'-[(tert-butyl)dimethylsilyloxy]-4'-hydroxycyclohexyl}adenine

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Chemical Property of N⁶-benzoyl-9-{2'-[(tert-butyl)dimethylsilyloxy]-4'-hydroxycyclohexyl}adenine

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Technology Process of N⁶-benzoyl-9-{2'-[(tert-butyl)dimethylsilyloxy]-4'-hydroxycyclohexyl}adenine

There total 11 articles about N⁶-benzoyl-9-{2'-[(tert-butyl)dimethylsilyloxy]-4'-hydroxycyclohexyl}adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 878550-01-7
N⁶-benzoyl-9-{2'-[(tert-butyl)dimethylsilyloxy]-4'-[(R)-2-methoxy-2-phenylacetoxy]cyclohexyl}adenine

: 878550-03-9
N⁶-benzoyl-9-{2'-[(tert-butyl)dimethylsilyloxy]-4'-hydroxycyclohexyl}adenine

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; methanol;
DOI:10.1002/hlca.200590258

Reference yield:

: (+/-)-5-amino-4-[(1'RS,2'RS,4'RS)-4'-(benzyloxy)-2'-hydroxycyclohexylamine]-6-chloropyrimidine

: 878550-03-9
N⁶-benzoyl-9-{2'-[(tert-butyl)dimethylsilyloxy]-4'-hydroxycyclohexyl}adenine

Guidance literature:: Multi-step reaction with 9 steps

1.1: HCl / 20 °C

1.2: 76 percent / HCl / tetrahydrofuran / 2 h / 20 °C

2.1: 84 percent / NH₃ / methanol / 100 °C

3.1: 81 percent / 1H-imidazole / dimethylformamide / 20 °C

4.1: 96 percent / NH₄OCOH / Pd/C / methanol / 7 h / Heating

5.1: pyridine / 1 h / 0 °C

6.1: pyridine / 20 °C

7.1: 521 mg / NH₄OH / H₂O; methanol / 0.5 h / 0 °C

8.1: 36 percent / N,N'-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h / 0 - 20 °C

9.1: 66 percent / NaOH / methanol; dioxane

With 1H-imidazole; hydrogenchloride; dmap; ammonium hydroxide; sodium hydroxide; ammonia; ammonium formate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200590258

Reference yield:

: (+/-)-9-[(1'RS,2'RS,4'RS)-4'-(benzyloxy)-2'-hydroxycyclohexyl]-6-chloropurine

: 878550-03-9
N⁶-benzoyl-9-{2'-[(tert-butyl)dimethylsilyloxy]-4'-hydroxycyclohexyl}adenine

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / NH₃ / methanol / 100 °C

2: 81 percent / 1H-imidazole / dimethylformamide / 20 °C

3: 96 percent / NH₄OCOH / Pd/C / methanol / 7 h / Heating

4: pyridine / 1 h / 0 °C

5: pyridine / 20 °C

6: 521 mg / NH₄OH / H₂O; methanol / 0.5 h / 0 °C

7: 36 percent / N,N'-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h / 0 - 20 °C

8: 66 percent / NaOH / methanol; dioxane

With 1H-imidazole; dmap; ammonium hydroxide; sodium hydroxide; ammonia; ammonium formate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200590258