N-[3,5-dicyano-6-(2-morpholin-4-yl-acetylamino)-4-phenyl-4H-thiopyran-2-yl]-2-morpholin-4-yl-acetamide

Base Information

• Chemical Name: N-[3,5-dicyano-6-(2-morpholin-4-yl-acetylamino)-4-phenyl-4H-thiopyran-2-yl]-2-morpholin-4-yl-acetamide
• CAS No.: 594874-96-1
• Molecular Formula: C₂₅H₂₈N₆O₄S
• Molecular Weight: 508.601

Synonyms:N-[3,5-dicyano-6-(2-morpholin-4-yl-acetylamino)-4-phenyl-4H-thiopyran-2-yl]-2-morpholin-4-yl-acetamide

Chemical Property of N-[3,5-dicyano-6-(2-morpholin-4-yl-acetylamino)-4-phenyl-4H-thiopyran-2-yl]-2-morpholin-4-yl-acetamide

Chemical Property:

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Technology Process of N-[3,5-dicyano-6-(2-morpholin-4-yl-acetylamino)-4-phenyl-4H-thiopyran-2-yl]-2-morpholin-4-yl-acetamide

There total 2 articles about N-[3,5-dicyano-6-(2-morpholin-4-yl-acetylamino)-4-phenyl-4H-thiopyran-2-yl]-2-morpholin-4-yl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

morpholine (110-91-8,99108-56-2) + 2-chloro-N-[6-(2-chloro-acetylamino)-3,5-dicyano-4-phenyl-4H-thiopyran-2-yl]-acetamide (594874-84-7) → N-[3,5-dicyano-6-(2-morpholin-4-yl-acetylamino)-4-phenyl-4H-thiopyran-2-yl]-2-morpholin-4-yl-acetamide (594874-96-1)

Guidance literature:

With triethylamine; In 1,4-dioxane; for 5h; Heating;

DOI:10.1080/10426500307793

Reference yield:

2,6-diamino-4-phenyl-3,5-dicyano-4H-thiopyran (102434-73-1) → N-[3,5-dicyano-6-(2-morpholin-4-yl-acetylamino)-4-phenyl-4H-thiopyran-2-yl]-2-morpholin-4-yl-acetamide (594874-96-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / Et₃N / dioxane / 5 h / Heating

2: 40 percent / Et₃N / dioxane / 5 h / Heating

With triethylamine; In 1,4-dioxane;

DOI:10.1080/10426500307793

Reference yield: 66.0%

N-[3,5-dicyano-6-(2-morpholin-4-yl-acetylamino)-4-phenyl-4H-thiopyran-2-yl]-2-morpholin-4-yl-acetamide (594874-96-1) → 4,5-diamino-3,6-di-morpholin-4-yl-10-phenyl-8,10-dihydro-1H-9-thia-1,8-diaza-anthracene-2,7-dione

Guidance literature:

With sodium t-butanolate; In dimethyl sulfoxide; tert-butyl alcohol; at 100 ℃; for 1h;

DOI:10.1080/10426500307793

upstream raw materials:

morpholine

2-chloro-N-[6-(2-chloro-acetylamino)-3,5-dicyano-4-phenyl-4H-thiopyran-2-yl]-acetamide

2,6-diamino-4-phenyl-3,5-dicyano-4H-thiopyran

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