ethyl 3-[3-[2-ethoxycarbonylacetyl-3-[4-(trifluoromethyl)phenyl]propionyl]-4-methoxyphenyl]-2-ethylpropanoate

Base Information

Chemical Name:ethyl 3-[3-[2-ethoxycarbonylacetyl-3-[4-(trifluoromethyl)phenyl]propionyl]-4-methoxyphenyl]-2-ethylpropanoate
CAS No.:378232-20-3
Molecular Formula:C₂₇H₃₁F₃O₆
Molecular Weight:508.535
Hs Code.:

Synonyms:ethyl 3-[3-[2-ethoxycarbonylacetyl-3-[4-(trifluoromethyl)phenyl]propionyl]-4-methoxyphenyl]-2-ethylpropanoate

Suppliers and Price of ethyl 3-[3-[2-ethoxycarbonylacetyl-3-[4-(trifluoromethyl)phenyl]propionyl]-4-methoxyphenyl]-2-ethylpropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 3-[3-[2-ethoxycarbonylacetyl-3-[4-(trifluoromethyl)phenyl]propionyl]-4-methoxyphenyl]-2-ethylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 3-[3-[2-ethoxycarbonylacetyl-3-[4-(trifluoromethyl)phenyl]propionyl]-4-methoxyphenyl]-2-ethylpropanoate

There total 6 articles about ethyl 3-[3-[2-ethoxycarbonylacetyl-3-[4-(trifluoromethyl)phenyl]propionyl]-4-methoxyphenyl]-2-ethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 402-49-3
4-bromomethyltrifluoromethylbenzene

: 378232-19-0
ethyl 3-[3-(2-ethoxycarbonylacetyl)-4-methoxyphenyl]-2-ethylpropanoate

: 378232-20-3
ethyl 3-[3-[2-ethoxycarbonylacetyl-3-[4-(trifluoromethyl)phenyl]propionyl]-4-methoxyphenyl]-2-ethylpropanoate

Guidance literature:: ethyl 3-[3-(2-ethoxycarbonylacetyl)-4-methoxyphenyl]-2-ethylpropanoate; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.833333h;

4-bromomethyltrifluoromethylbenzene; In tetrahydrofuran; for 6h; Heating;
DOI:10.1021/jm0205144

Reference yield:

: 17145-91-4
triethyl 2-ethylphosphonoacetate

: 378232-20-3
ethyl 3-[3-[2-ethoxycarbonylacetyl-3-[4-(trifluoromethyl)phenyl]propionyl]-4-methoxyphenyl]-2-ethylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / tetrahydrofuran / 1 h

1.2: tetrahydrofuran / 4 h / 0 - 20 °C

2.1: H₂ / Pd/C / tetrahydrofuran; ethanol / 2192.43 Torr

3.1: AlCl₃ / CH₂Cl₂ / 0.5 h / 20 °C

3.2: 49 percent / CH₂Cl₂ / 0 - 20 °C

4.1: NaH / diethyl ether / 0.5 h / 20 °C

4.2: 58 percent / diethyl ether; ethanol / 6 h / Heating

5.1: NaH / tetrahydrofuran / 0.83 h / 0 - 20 °C

5.2: 98 percent / tetrahydrofuran / 6 h / Heating

With aluminium trichloride; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jm0205144

Reference yield:

: 53618-36-3
ethyl 2-ethyl-3-(4-methoxyphenyl)acrylate

: 378232-20-3
ethyl 3-[3-[2-ethoxycarbonylacetyl-3-[4-(trifluoromethyl)phenyl]propionyl]-4-methoxyphenyl]-2-ethylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: H₂ / Pd/C / tetrahydrofuran; ethanol / 2192.43 Torr

2.1: AlCl₃ / CH₂Cl₂ / 0.5 h / 20 °C

2.2: 49 percent / CH₂Cl₂ / 0 - 20 °C

3.1: NaH / diethyl ether / 0.5 h / 20 °C

3.2: 58 percent / diethyl ether; ethanol / 6 h / Heating

4.1: NaH / tetrahydrofuran / 0.83 h / 0 - 20 °C

4.2: 98 percent / tetrahydrofuran / 6 h / Heating

With aluminium trichloride; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jm0205144