1-{[4-(cyclopropylmethoxy)-3-(pyridin-2-ylethynyl)phenyl]carbonyl}-4-pyridin-2-ylpiperazine

Base Information

Chemical Name:1-{[4-(cyclopropylmethoxy)-3-(pyridin-2-ylethynyl)phenyl]carbonyl}-4-pyridin-2-ylpiperazine
CAS No.:1197356-97-0
Molecular Formula:C₂₇H₂₆N₄O₂
Molecular Weight:438.529
Hs Code.:

Synonyms:1-{[4-(cyclopropylmethoxy)-3-(pyridin-2-ylethynyl)phenyl]carbonyl}-4-pyridin-2-ylpiperazine

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Chemical Property of 1-{[4-(cyclopropylmethoxy)-3-(pyridin-2-ylethynyl)phenyl]carbonyl}-4-pyridin-2-ylpiperazine

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Technology Process of 1-{[4-(cyclopropylmethoxy)-3-(pyridin-2-ylethynyl)phenyl]carbonyl}-4-pyridin-2-ylpiperazine

There total 4 articles about 1-{[4-(cyclopropylmethoxy)-3-(pyridin-2-ylethynyl)phenyl]carbonyl}-4-pyridin-2-ylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 34803-66-2
1-(2-pyridyl)piperazine

: 1197357-90-6
4-(cyclopropylmethoxy)-3-(pyridin-2-ylethynyl)benzoic acid

: 1197356-97-0
1-{[4-(cyclopropylmethoxy)-3-(pyridin-2-ylethynyl)phenyl]carbonyl}-4-pyridin-2-ylpiperazine

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 15126-06-4
methyl 3-iodo-4-hydroxybenzoate

: 1197356-97-0
1-{[4-(cyclopropylmethoxy)-3-(pyridin-2-ylethynyl)phenyl]carbonyl}-4-pyridin-2-ylpiperazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 6 h / 100 °C / Inert atmosphere

3.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 20 °C

3.2: pH 4

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

With copper(l) iodide; lithium hydroxide monohydrate; water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1197357-87-1
methyl 4-(cyclopropylmethoxy)-3-iodobenzoate

: 1197356-97-0
1-{[4-(cyclopropylmethoxy)-3-(pyridin-2-ylethynyl)phenyl]carbonyl}-4-pyridin-2-ylpiperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 6 h / 100 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 20 °C

2.2: pH 4

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

With copper(l) iodide; lithium hydroxide monohydrate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; dichloromethane; toluene;