({4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]-phenyl}methyl)amine

Base Information

Chemical Name:({4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]-phenyl}methyl)amine
CAS No.:937598-87-3
Molecular Formula:C₁₅H₁₆F₃N₃
Molecular Weight:295.307
Hs Code.:

Synonyms:({4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]-phenyl}methyl)amine

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Chemical Property of ({4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]-phenyl}methyl)amine

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Technology Process of ({4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]-phenyl}methyl)amine

There total 3 articles about ({4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]-phenyl}methyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 950785-30-5
{4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]-phenyl}acetonitrile

: 937598-87-3
({4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]-phenyl}methyl)amine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; Inert atmosphere; Cooling with ice;
DOI:10.1021/jm100679e

Reference yield:

: 890005-22-8,35179-55-6
3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

: 937598-87-3
({4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]-phenyl}methyl)amine

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; trans-1,2-Diaminocyclohexane; potassium carbonate / 1,4-dioxane / 0.58 h / 180 °C / Microwave irradiation

2: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice

With copper(l) iodide; lithium aluminium tetrahydride; trans-1,2-Diaminocyclohexane; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; 1: Ullmann reaction;
DOI:10.1021/jm100679e

Reference yield:

: 3058-39-7
4-iodobenzonitrile

: 937598-87-3
({4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]-phenyl}methyl)amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / copper(l) iodide; dimethylaminoacetic acid / dimethyl sulfoxide / 4 h / 130 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.75 h / 0 - 20 °C

2.2: 0 °C

With lithium aluminium tetrahydride; caesium carbonate; copper(l) iodide; dimethylaminoacetic acid; In tetrahydrofuran; dimethyl sulfoxide;