methyl 3-(5-bromo-2-fluorophenyl)-3-((S)-1,1-dimethylethylsulfinamido)-4,4-difluorobutanoate

Base Information

Chemical Name:methyl 3-(5-bromo-2-fluorophenyl)-3-((S)-1,1-dimethylethylsulfinamido)-4,4-difluorobutanoate
CAS No.:1414877-20-5
Molecular Formula:C₁₅H₁₉BrF₃NO₃S
Molecular Weight:430.286
Hs Code.:

Synonyms:methyl 3-(5-bromo-2-fluorophenyl)-3-((S)-1,1-dimethylethylsulfinamido)-4,4-difluorobutanoate

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Chemical Property of methyl 3-(5-bromo-2-fluorophenyl)-3-((S)-1,1-dimethylethylsulfinamido)-4,4-difluorobutanoate

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Technology Process of methyl 3-(5-bromo-2-fluorophenyl)-3-((S)-1,1-dimethylethylsulfinamido)-4,4-difluorobutanoate

There total 4 articles about methyl 3-(5-bromo-2-fluorophenyl)-3-((S)-1,1-dimethylethylsulfinamido)-4,4-difluorobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.7%

: 79-20-9
acetic acid methyl ester

: 1414877-14-7
(S,E)-N-(1-(5-bromo-2-fluorophenyl)-2,2-difluoroethylidene)-2-methylpropane-2-sulfinamide

: 1414877-20-5
methyl 3-(5-bromo-2-fluorophenyl)-3-((S)-1,1-dimethylethylsulfinamido)-4,4-difluorobutanoate

Guidance literature:: acetic acid methyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 0.5h;

With triisopropoxytitanium(IV) chloride; In tetrahydrofuran; at -70 ℃; for 0.5h;

(S,E)-N-(1-(5-bromo-2-fluorophenyl)-2,2-difluoroethylidene)-2-methylpropane-2-sulfinamide; In tetrahydrofuran; at -70 ℃; for 2h;

Reference yield:

: chlorotitanium triisopropoxide

: (S,E)-N-(1-(5-bromo-2-fluorophenyl)-2,2-difluoroethylidene)-2-methylpropane-2-sulfinamide

: ammonium chloride

: 1414877-20-5
methyl 3-(5-bromo-2-fluorophenyl)-3-((S)-1,1-dimethylethylsulfinamido)-4,4-difluorobutanoate

Guidance literature:: With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; acetic acid methyl ester;

Reference yield:

: 1262858-97-8
1-(5-bromo-2-fluorophenyl)-2,2-difluoroethanone

: 1414877-20-5
methyl 3-(5-bromo-2-fluorophenyl)-3-((S)-1,1-dimethylethylsulfinamido)-4,4-difluorobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 3 h / 23 - 70 °C

2.1: diisopropylamine; n-butyllithium / triisopropoxytitanium(IV) chloride / hexane; tetrahydrofuran / 0.5 h / -70 °C

2.2: 2 h / -70 °C

With titanium(IV) tetraethanolate; n-butyllithium; diisopropylamine; triisopropoxytitanium(IV) chloride; In tetrahydrofuran; hexane;